公开(公告)号：US20180014971A1

公开(公告)日：2018-01-18

申请号：US15714518

申请日：2017-09-25

申请人： University of Washington ,  Washington University in St. Louis

发明人： Raimondo D'Ambrosio ,  Samuel R. Browd ,  John W. Miller ,  Jeffrey G. Ojemann ,  Clifford L. Eastman ,  Matthew Smyth ,  Steven M. Rothman ,  Jason Fender

IPC分类号： A61F7/12 ,  A61F7/00

CPC分类号： A61F7/12 ,  A61F2007/0002

摘要： The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological abnormalities using a thermally conductive graft including a thermally conductive matrix disposed between two opposed surfaces.

公开(公告)号：US10517755B2

公开(公告)日：2019-12-31

申请号：US15351345

申请日：2016-11-14

申请人： University of Washington ,  Washington University ,  Regents of the University of Minnesota

发明人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller ,  Matthew Smyth ,  Steven M. Rothman

IPC分类号： A61F7/12 ,  A61F7/10 ,  A61F7/00 ,  A61F7/02

摘要： Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2° C. has been found effective at inhibiting seizures.

公开(公告)号：US20170056240A1

公开(公告)日：2017-03-02

申请号：US15351345

申请日：2016-11-14

申请人： University of Washington ,  Washington University ,  Regents of the University of Minnesota

发明人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller ,  Matthew Smyth ,  Steven M. Rothman

IPC分类号： A61F7/12 ,  A61F7/10

CPC分类号： A61F7/12 ,  A61F7/10 ,  A61F2007/0002 ,  A61F2007/0096 ,  A61F2007/0247 ,  A61F2007/108 ,  A61F2007/126

摘要： Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2° C. has been found effective at inhibiting seizures.

摘要翻译： 公开了用于灶脑冷却的被动修复装置和抑制癫痫发作的方法。 假体装置用具有接触相对温暖的脑膜或脑的内表面的导热插入物和接触相对较冷的头皮的外表面替换绝热骨瓣。 在一个实施例中，假体是一体的; 在另一个中，生物相容性壳体填充有高度导电的芯; 另一方面，将填充的聚合物嵌段连接到板上; 另一方面，骨折片填充有导电聚合物。 在一个实施方案中，含有表现出磁热效应的元素的填充聚合物提供可以通过施加合适的磁场而增强的热传递。 发现低至1.2℃的局部冷却有效抑制癫痫发作。