公开(公告)号：US10071964B2

公开(公告)日：2018-09-11

申请号：US15560580

申请日：2016-03-22

申请人： Univerza V Ljubljani

发明人： Boris Brus ,  Urban Kosak ,  Damijan Knez ,  Nicolas Coquelle ,  Jacques-Philippe Colletier ,  Stanislav Gobec

IPC分类号： A61K31/445 ,  C07D211/06 ,  C07D211/28 ,  A61K31/4523 ,  A61K31/453 ,  A61K31/4709 ,  C07D401/12 ,  C07D405/12 ,  C07D211/26

CPC分类号： C07D211/28 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/453 ,  A61K31/4709 ,  C07D211/26 ,  C07D401/12 ,  C07D405/12

摘要： This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of Alzheimer's disease and other forms of dementia.