公开(公告)号：US06635627B1

公开(公告)日：2003-10-21

申请号：US09424785

申请日：1999-11-29

申请人： Véronique Stoven ,  Gérard Lenoir ,  Jean-Yves Lallemand ,  Jean-Philippe Annereau ,  Joël Barthe ,  Sylvain Blanquet

发明人： Véronique Stoven ,  Gérard Lenoir ,  Jean-Yves Lallemand ,  Jean-Philippe Annereau ,  Joël Barthe ,  Sylvain Blanquet

IPC分类号： A61K3166

CPC分类号： A61K31/00 ,  A61K31/165 ,  A61K31/198 ,  A61K31/475 ,  A61K31/675 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

摘要： The invention concerns a novel approach for treating cystic fibrosis using, in particular, anti-cancer chemotherapy. For the treatment of cystic fibrosis it proposes the use of at least one product which when administered to a patient brings about the expression or overexpression of an ABC carrier compound, in particular glutathione carrier. Preferably, the products used are anti-cancer products whose administration brings about the expression of MRP and/or MDR protein. The invention is also applicable to the treatment of rheumatoid polyarthritis or asthma. More specifically, the compounds are selected among cyclophosphamide, aclarubicin, doxorubicin, daunorubicin, epirubicin, idarubicin, zorubicin, pirabucin, colchicine, videsine, vinorelbine, vincristine, binblasine, azithromycin, erythromycin, ifosmamide, N-acetyl cysteine, N-acetyl lysine and/or a CFTR protein fragment comprising the NBF1 domain.

摘要翻译： 本发明涉及使用特别是抗癌化学疗法治疗囊性纤维化的新方法。 对于囊性纤维化的治疗，它提出使用至少一种产品，其在给予患者时引起ABC载体化合物，特别是谷胱甘肽载体的表达或过表达。 优选地，所用的产品是抗癌产品，其给药引起MRP和/或MDR蛋白的表达。 本发明也适用于治疗类风湿关节炎或哮喘。 更具体地说，这些化合物选自环磷酰胺，阿柔比星，多柔比星，柔红霉素，表柔比星，伊达比星，佐立菌素，比拉布丁，秋水仙素，维生素，长春瑞滨，长春新碱，双倍体碱，阿奇霉素，红霉素，异环酰胺，N-乙酰半胱氨酸，N-乙酰基赖氨酸和 /或包含NBF1结构域的CFTR蛋白片段。

公开(公告)号：US06699204B1

公开(公告)日：2004-03-02

申请号：US09937424

申请日：2002-03-05

申请人： Georges Kehyayan ,  Ivan Kehayoff ,  Gérard Lenoir ,  Christian Avedissian ,  Bruno Roux

发明人： Georges Kehyayan ,  Ivan Kehayoff ,  Gérard Lenoir ,  Christian Avedissian ,  Bruno Roux

IPC分类号： A61B508

CPC分类号： A61B7/003

摘要： The invention concerns a device for analysing medical sounds, in particular respiratory sounds, comprising an input receiving a sound signal sampled in intensity levels each associated with a selected time, and storage means (2, 4, 5) comprising a processing module for evaluating, in cooperation with computing means (3), a set of transformed intensity levels, each associated with a predetermined sound frequency. It further comprises an output (26) connected to the storage means (2) for delivering each transformed intensity level in correspondence with an associated frequency, and means for representing (6, 90, 91) intensity levels transformed on the basis of frequencies, to obtain a spectral representation of the auscultation sound. The invention is characterised in that the processing module is further capable of evaluating a set of transformed intensity levels for each selected time, and the storage means (2) store each intensity level transformed on the basis of an associated frequency, and of a selected time, thereby providing a three-dimensional representation in time and in frequencies of the auscultation sound.

摘要翻译： 本发明涉及一种用于分析医疗声音，特别是呼吸声音的装置，包括接收以每个与所选择的时间相关联的强度级别采样的声音信号的输入端，以及包括处理模块的存储装置（2,4,5） 与计算装置（3）协作，一组变换的强度级别，每一个与预定的声音频率相关联。 它还包括连接到存储装置（2）的输出（26），用于传送与相关频率相对应的每个变换的强度电平;以及用于表示（6,90,91）基于频率变换的强度电平的装置， 获得听诊声音的频谱表示。 本发明的特征在于，处理模块还能够针对每个选定的时间评估一组变换的强度级别，并且存储装置（2）存储基于相关联的频率和选定时间变换的每个强度级别 从而在听诊声音的时间和频率上提供三维表示。