公开(公告)号：US20200253974A1

公开(公告)日：2020-08-13

申请号：US16500369

申请日：2017-05-17

Applicant: VANDERBILT UNIVERSITY

Inventor： Alex G. Waterson ,  Jason R. Abbott ,  J. Phillip Kennedy ,  Stephen W. Fesik ,  Qi Sun ,  Jason Phan ,  Michael C. Burns ,  Pratiq Patel

IPC: A61K31/517 ,  C07D239/95 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14 ,  C07D403/12 ,  C07D401/10 ,  C07D403/10 ,  C07D401/14 ,  C07D413/14 ,  A61K31/5377 ,  C07D413/10

Abstract: The present invention relates to quinazoline compounds and compositions that modulate Ras signaling. Compounds and compositions of the present invention are useful in the treatment of cancers and other disease states associated with Ras dysfunction (e.g., Ras-associated autoimmune leukoproliferative disorder, or certain types of mitochondrial dysfunction) in a subject, for example a mammal or a human.

公开(公告)号：US11318137B2

公开(公告)日：2022-05-03

申请号：US16500369

申请日：2017-05-17

Applicant: VANDERBILT UNIVERSITY

Inventor： Alex G. Waterson ,  Jason R. Abbott ,  J. Phillip Kennedy ,  Stephen W. Fesik ,  Qi Sun ,  Jason Phan ,  Michael C. Burns ,  Pratiq Patel

IPC: C07D239/95 ,  A61K31/517 ,  A61K31/5377 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/14

Abstract: The present invention relates to quinazoline compounds and compositions that modulate Ras signaling. Compounds and compositions of the present invention are useful in the treatment of cancers and other disease states associated with Ras dysfunction (e.g., Ras-associated autoimmune leukoproliferative disorder, or certain types of mitochondrial dysfunction) in a subject, for example a mammal or a human.