公开(公告)号：US11326196B2

公开(公告)日：2022-05-10

申请号：US16069404

申请日：2017-01-10

申请人： VILNIUS UNIVERSITY ,  ETH ZURICH

发明人： Linas Mazutis ,  Greta Stonyte ,  Vaidotas Kiseliovas ,  Rapolas Zilionis ,  Arvydas Janulaitis ,  Robertas Galinis ,  Sabine Studer ,  Donald Hilvert

IPC分类号： C12P19/34 ,  B01J19/00 ,  A61K9/50 ,  B01L3/00

摘要： Disclosed is a system and method for production of DNA particles and use thereof. The DNA particles can be produced by amplification of nucleic acid molecule(s). Alternatively, DNA particles can be prepared by condensing multiple DNA molecules. The DNA condensation into a particle is mainly triggered by pyrophosphate and positively charged cations (e.g. magnesium). DNA particles can be applied for numerous biological applications but not limited to directed evolution, proteomics, drug delivery and imaging. DNA particles can be used to synthesize proteins using in vitro transcription/translation reaction.