公开(公告)号：US20080200769A1

公开(公告)日：2008-08-21

申请号：US11676128

申请日：2007-02-16

申请人： VINOD SHARMA ,  Xiaohong Zhou

发明人： VINOD SHARMA ,  Xiaohong Zhou

IPC分类号： A61N5/06

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。