公开(公告)号：US20250064971A1

公开(公告)日：2025-02-27

申请号：US18727821

申请日：2023-02-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Qingguo XU ,  Chaolong QIN ,  Tuo MENG ,  Aji Alex Moothedathu RAYNOLD ,  Matthew BANKS

IPC: A61K47/69 ,  A61K47/54

Abstract: A method of delivering an active ingredient to a subject in need thereof is provided. The method includes administering to the subject a therapeutically effective amount of a formulation comprising biodegradable, polymeric microparticles and an active ingredient selected from the group consisting of levo-alpha-acetylmethadol (LAAM), nor-LAAM, and dinor-LAAM, wherein the active ingredient is part of a hydrophobic ion-pairing (HIP) complex and wherein the HIP complex is associated with the microparticles. Sustained release formulations containing an active ingredient are also provided.