公开(公告)号：US20160011207A1

公开(公告)日：2016-01-14

申请号：US14648802

申请日：2013-12-05

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Youngman OH

IPC: G01N33/68 ,  C07K7/06

CPC classification number: G01N33/6893 ,  C07K7/06 ,  G01N2333/47 ,  G01N2333/4745 ,  G01N2800/04 ,  G01N2800/044

Abstract: Methods and compositions for the diagnosis and treatment of chronic inflammation (obesity)-induced disorders such as insulin resistance, diabetes, cancer and various metabolic disorders, are provided. The methods and compositions detect both full-blown disease and early stage disease by detecting proteolysis, by neutrophil proteases, of insulin-like growth factor binding protein-3 (IGFBP3). Levels of proteolytic fragments of IGFBP3 and/or levels of intact IGFPB-3 and/or levels/activity neutrophil proteases are detected. Agents (e.g. peptide agents) that inhibit the proteolysis of IGFPB-3 and methods of using the agents to prevent and treat chronic inflammation (obesity)-induced disorders are also provided.

Abstract translation: 提供了用于诊断和治疗慢性炎症（肥胖）诱导的疾病如胰岛素抵抗，糖尿病，癌症和各种代谢紊乱的方法和组合物。 方法和组合物通过中性粒细胞蛋白酶，胰岛素样生长因子结合蛋白-3（IGFBP3）的蛋白水解检测全发病和早期疾病。 检测IGFBP3的蛋白水解片段水平和/或完整IGFPB-3水平和/或水平/活性嗜中性粒细胞蛋白酶的水平。 还提供了抑制IGFPB-3的蛋白水解的试剂（例如肽试剂）和使用该试剂来预防和治疗慢性炎症（肥胖）诱导的病症的方法。

公开(公告)号：US20220152177A1

公开(公告)日：2022-05-19

申请号：US17532397

申请日：2021-11-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Youngman OH ,  Qing CAI

IPC: A61K39/00 ,  C07K16/28

Abstract: Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) agonists and methods of their use to treat diseases involving IGFBP-3 and IGFBP-3R are provided. The agonists may be antibodies or other molecules specific for binding to and activating IGFBP-3R. The agonists are used to treat e.g. cancer, metabolic syndrome and obstructive respiratory disorders. In addition, methods of diagnosing cancer and predicting the chance of recurrence, metastasis and/or survival by measuring the level of IGFBP-3R in tumor tissue are provided.

公开(公告)号：US20190270808A1

公开(公告)日：2019-09-05

申请号：US16346353

申请日：2017-10-31

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Youngman OH ,  Mikhail DOZMOROV ,  Qing CAI

IPC: C07K16/28 ,  C12Q1/6886 ,  A61P35/00 ,  A61P3/08

Abstract: Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) agonists and methods of their use to treat diseases involving IGFBP-3 and IGFBP-3R are provided. The agonists may be antibodies or other molecules specific for binding to and activating IGFBP-3R. The agonists are used to treat e.g. cancer, metabolic syndrome and obstructive respiratory disorders. In addition, methods of diagnosing cancer and predicting the chance of recurrence, metastasis and/or survival by measuring the level of IGFBP-3R in tumor tissue are provided.