公开(公告)号：US20210238181A1

公开(公告)日：2021-08-05

申请号：US17049232

申请日：2019-04-22

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Webster L. SANTOS ,  Yumin DAI ,  Jose A. SANTIAGO-RIVERA ,  Jacob H. MURRAY

IPC: C07D487/04 ,  C07D471/04 ,  C07D498/04 ,  A61P3/04

Abstract: The disclosure provides compounds of Formula (I-A) and (I-B) and the pharmaceutically acceptable salts thereof. The variables, R, R2, R3, X1, X2, X3, Y1, Y, and Z are defined herein. Certain compounds of Formula (I-A) and (I-B) act as selective mitochondrial protonophore uncouplers that do not affect plasma membrane potential. These compounds are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH), Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, the compounds are useful for increasing lifespan. Compounds and salts of Formulae (I-A) and (I-B) are also useful for regulating glucose homeostasis or insulin action in a patient.