专利检索 ap:("VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.") AND inv:"Sriranganathan Nammalwar" 第 1 页

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发明授权
Multivalent Brucella vaccine for protection against mycobacterial infections and methods of using the same 有权

公开(公告)号：US10406219B2

公开(公告)日：2019-09-10

申请号：US15509381

申请日：2015-09-08

申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

发明人： Sriranganathan Nammalwar , Hamzeh Al Qublan , Garrett Smith , Stephen Boyle , Gerhardt Schurig

IPC分类号： A61K39/04 , A61K45/06 , A61K35/74 , C07K14/35 , C12N1/20 , C12N15/74 , A61K39/00

摘要： Provided herein is a multivalent Brucella vaccine expressing at least one heterologous M. tuberculosis antigen. The vaccines described herein serve as an environmentally safe bivalent vaccine for protection against Brucella and Mycobacterium infections simultaneously. In particular, a multivalent vaccine comprising a Brucella strain transformed with a vector that expresses at least one M. tuberculosis antigen, where the M. tuberculosis antigen(s) is codon optimized for the Brucella strain is provided. In some aspects, the Brucella strain is B. abortus strain RB51 leuB and the M. tuberculosis antigen is one or more of Ag85B, Rv2660c, and ESAT6.