公开(公告)号：US20230313264A1

公开(公告)日：2023-10-05

申请号：US18011545

申请日：2021-07-01

Applicant: VISION DIAGNOSTICS, INC.

Inventor： JERRY W. DENNEY

IPC: C12Q1/42

CPC classification number: C12Q1/42

Abstract: A kit comprising two reagents for conducting two different Assays to measure a zinc-activated enzyme in a bodily fluid. The assay results are utilized to obtain a relative zinc-activated enzyme activity value that can be correlated to tissue zinc levels. A more specific embodiment utilizes two paired reagents for conducting an A Assay and a B Assay that measure different alkaline phosphatase (ALP) activities in a urine sample to obtain a Relative Renal Alkaline Phosphatase Activity (RRAPA) value. The RRAPA value can be correlated to zinc levels in renal tissue.

公开(公告)号：US20220128540A1

公开(公告)日：2022-04-28

申请号：US17570413

申请日：2022-01-07

Applicant: VISION DIAGNOSTICS, INC.

Inventor： JERRY W. DENNEY

IPC: G01N33/487 ,  G01N33/537 ,  G01N33/52 ,  G01N33/539 ,  G01N33/493

Abstract: Assays and methods for verifying the validity of a urine sample submitted for Drugs of Abuse (DOA) testing. Embodiments include a SUD Diagnostic Panel that includes six assays: specific gravity index assay, long-duration counterfeit urine assay, short-duration counterfeit urine assay, oxidant history assay, pH assay, and creatinine assay. The SUD Diagnostic Panel detects twelve principle classes of adulteration. Detection of adulteration of one or more urine samples from a patient indicates an attempt to subvert test results and provides an objective indication in one instance and an object diagnosis in another instance of SUD.