公开(公告)号：US10807959B2

公开(公告)日：2020-10-20

申请号：US16543303

申请日：2019-08-16

Applicant: Vanderbilt University

Inventor： Rocco D. Gogliotti ,  Shaun R. Stauffer ,  KyuOk Jeon ,  James M. Salovich ,  Jonathan D. Macdonald ,  Jonathan J. Mills ,  Kenneth M. Meyers ,  Joseph R. Alvarado ,  Changho Han ,  Stephen W. Fesik ,  Taekyu Lee

IPC: C07D233/48 ,  C07D401/12 ,  C07D401/14 ,  C07D207/22 ,  C07D401/06 ,  C07D405/12 ,  C07D233/26 ,  C07D413/12 ,  C07D263/28 ,  C07D213/58

Abstract: Benzamides and picolinamides that are meta-substituted with imino-, guanidino-, or heterocycle-containing groups disrupt the WDR5-MLL1 protein-protein interaction, and have use in pharmaceutical compositions and in treating proliferative disorders and conditions in a subject, such as cancer.

公开(公告)号：US20200055824A1

公开(公告)日：2020-02-20

申请号：US16543303

申请日：2019-08-16

Applicant: Vanderbilt University

Inventor： Rocco D. Gogliotti ,  Shaun R. Stauffer ,  KyuOk Jeon ,  James M. Salovich ,  Jonathan D. Macdonald ,  Jonathan J. Mills ,  Kenneth M. Meyers ,  Joseph R. Alvarado ,  Changho Han ,  Stephen W. Fesik ,  Taekyu Lee

IPC: C07D233/48 ,  C07D401/12 ,  C07D401/14 ,  C07D207/22 ,  C07D213/58 ,  C07D405/12 ,  C07D233/26 ,  C07D413/12 ,  C07D263/28 ,  C07D401/06

Abstract: Benzamides and picolinamides that are meta-substituted with imino-, guanidino-, or heterocycle-containing groups disrupt the WDR5-MLL1 protein-protein interaction, and have use in pharmaceutical compositions and in treating proliferative disorders and conditions in a subject, such as cancer.