公开(公告)号：US10807959B2

公开(公告)日：2020-10-20

申请号：US16543303

申请日：2019-08-16

Applicant: Vanderbilt University

Inventor： Rocco D. Gogliotti ,  Shaun R. Stauffer ,  KyuOk Jeon ,  James M. Salovich ,  Jonathan D. Macdonald ,  Jonathan J. Mills ,  Kenneth M. Meyers ,  Joseph R. Alvarado ,  Changho Han ,  Stephen W. Fesik ,  Taekyu Lee

IPC: C07D233/48 ,  C07D401/12 ,  C07D401/14 ,  C07D207/22 ,  C07D401/06 ,  C07D405/12 ,  C07D233/26 ,  C07D413/12 ,  C07D263/28 ,  C07D213/58

Abstract: Benzamides and picolinamides that are meta-substituted with imino-, guanidino-, or heterocycle-containing groups disrupt the WDR5-MLL1 protein-protein interaction, and have use in pharmaceutical compositions and in treating proliferative disorders and conditions in a subject, such as cancer.

公开(公告)号：US20200055824A1

公开(公告)日：2020-02-20

申请号：US16543303

申请日：2019-08-16

Applicant: Vanderbilt University

Inventor： Rocco D. Gogliotti ,  Shaun R. Stauffer ,  KyuOk Jeon ,  James M. Salovich ,  Jonathan D. Macdonald ,  Jonathan J. Mills ,  Kenneth M. Meyers ,  Joseph R. Alvarado ,  Changho Han ,  Stephen W. Fesik ,  Taekyu Lee

IPC: C07D233/48 ,  C07D401/12 ,  C07D401/14 ,  C07D207/22 ,  C07D213/58 ,  C07D405/12 ,  C07D233/26 ,  C07D413/12 ,  C07D263/28 ,  C07D401/06

Abstract: Benzamides and picolinamides that are meta-substituted with imino-, guanidino-, or heterocycle-containing groups disrupt the WDR5-MLL1 protein-protein interaction, and have use in pharmaceutical compositions and in treating proliferative disorders and conditions in a subject, such as cancer.

公开(公告)号：US11999716B2

公开(公告)日：2024-06-04

申请号：US17287492

申请日：2019-10-24

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  Joseph R. Alvarado ,  Jianhua Tian ,  Kenneth M. Meyers ,  Changho Han ,  Jonathan J. Mills ,  Kevin B. Teuscher ,  Shaun R. Stauffer ,  Stephen W. Fesik ,  Rocco D. Gogliotti

IPC: C07D401/14 ,  C07D217/16 ,  C07D401/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04

CPC classification number: C07D401/14 ,  C07D217/16 ,  C07D401/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04

Abstract: Isoquinolinone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

公开(公告)号：US20230012362A1

公开(公告)日：2023-01-12

申请号：US17287492

申请日：2019-10-24

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  Joseph R. Alvarado ,  Jianhua Tian ,  Kenneth M. Meyers ,  Changho Han ,  Jonathan J. Mills ,  Kevin B. Teuscher ,  Shaun R. Stauffer ,  Stephen W. Fesik

IPC: C07D401/14 ,  C07D401/06 ,  C07D487/04 ,  C07D405/14 ,  C07D417/14 ,  C07D417/06 ,  C07D413/14 ,  C07D217/16 ,  C07D413/06

Abstract: Isoquinolinone compounds and derivatives inhibit WDRS and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

公开(公告)号：US20220289673A1

公开(公告)日：2022-09-15

申请号：US17631114

申请日：2020-07-29

Applicant: Vanderbilt University

Inventor： William P. Tansey ,  Stephen W. Fesik ,  Shaun R. Stauffer ,  Alex G. Waterson ,  Changho Han ,  Joseph R. Alvarado ,  Jonathan D. MacDonald ,  Selena Chacon Simon ,  Sameer S. Nikhar ,  Alexey Kuznetsov

IPC: C07C311/21 ,  C07C311/29 ,  C07C311/39 ,  C07C311/43 ,  C07C317/34 ,  C07C317/38 ,  C07C317/48 ,  C07C323/49 ,  C07C381/00 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/48 ,  C07D207/27 ,  C07D213/40 ,  C07D213/56 ,  C07D213/64 ,  C07D215/36 ,  C07D233/36 ,  C07D239/26 ,  C07D249/14 ,  C07D265/30 ,  C07D241/04 ,  C07D305/08 ,  C07D307/14 ,  C07D307/18 ,  C07D307/22 ,  C07D307/52 ,  C07D307/79 ,  C07D309/04 ,  C07D309/10 ,  C07D309/14 ,  C07D309/22 ,  C07D333/20 ,  C07D333/24

Abstract: Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.