公开(公告)号：US10329304B2

公开(公告)日：2019-06-25

申请号：US15452551

申请日：2017-03-07

Applicant: Vanderbilt University

Inventor： Charles C. Hong ,  Charles H. Williams ,  Jonathan Hempel ,  T K Feaster ,  Don H. Rubin ,  Gary Sulikowski ,  Jijun Hao ,  Audrey Frist

IPC: C07D495/14 ,  C07D495/04 ,  C07D409/12 ,  C07D471/04 ,  C07D333/38 ,  A61K45/06 ,  A61K9/00 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/517 ,  A61K31/381

Abstract: Compounds and compositions, and methods of use thereof, are provided and have utility in inhibiting hedgehog signaling and/or phosphodiesterase-4 activity.