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1.发明申请公开(公告)号：US20100092995A1
公开(公告)日：2010-04-15
申请号：US12443850
申请日：2007-10-07
IPC分类号： G01N33/53 , C07D311/02
CPC分类号： C07F15/0053 , A61K49/0019 , A61K49/0041 , A61K49/0043
摘要： A fluorescent compound exhibiting a high affinity to calcium-binding proteins (CaBP) is provided. The compound, containing ruthenium, enables to detect, identify, and isolate CaBPs involved in cellular signaling and regulation. The compound is employed for diagnosing a disorder associated with CaBPs defects.
摘要翻译： 提供了对钙结合蛋白（CaBP）具有高亲和力的荧光化合物。 含有钌的化合物能够检测，鉴定和分离参与细胞信号传导和调节的CaBPs。 该化合物用于诊断与CaBPs缺陷相关的病症。
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2.发明授权公开(公告)号：US08034314B2
公开(公告)日：2011-10-11
申请号：US10589170
申请日：2005-02-17
CPC分类号： C07K14/4728 , A61K38/00 , A61K41/0042 , A61K51/02 , G01N2333/4727
摘要： The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparation of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the function of a Ca2+-binding protein, and in the preparation of a medicament for treating such disorders.
摘要翻译： 本发明提供了光敏反应试剂，其特异性结合Ca 2+结合蛋白，在光活化后与它们共价连接并标记它们。 该新型试剂能够表征，纯化，抑制和筛选Ca2 +结合蛋白，以及制备新的亲和层析基质和新的蛋白质生物传感器。 本发明还涉及试剂在抑制细胞凋亡和坏死中的用途，以及用于诊断与Ca 2+结合蛋白的功能缺陷相关的病症以及用于治疗这些疾病的药物的制备。
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3.发明申请公开(公告)号：US20070298120A1
公开(公告)日：2007-12-27
申请号：US10589170
申请日：2005-02-17
CPC分类号： C07K14/4728 , A61K38/00 , A61K41/0042 , A61K51/02 , G01N2333/4727
摘要： The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparation of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the function of a Ca2+-binding protein, and in the preparation of a medicament for treating such disorders.
摘要翻译： 本发明提供了一种特异性结合Ca 2+结合蛋白质的光反应试剂，其在光激活后共价连接并标记它们。 该新型试剂能够表征，纯化，抑制和筛选Ca 2+结合蛋白，以及制备新的亲和层析基质和新的蛋白质生物传感器。 本发明还涉及试剂在抑制细胞凋亡和坏死中的用途，以及诊断与Ca 2+结合蛋白的功能缺陷相关的病症，以及制备药物 用于治疗这种疾病。
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