公开(公告)号：US11248026B2

公开(公告)日：2022-02-15

申请号：US15683355

申请日：2017-08-22

申请人： Variation Biotechnologies Inc. ,  Sorbonne Université

发明人： David E. Anderson ,  Anne-Catherine Fluckiger ,  David Klatzmann ,  Charlotte Dalba-Fribert

IPC分类号： A61K39/12 ,  A61P31/22 ,  C07K14/005 ,  A61K39/245 ,  A61K39/00

摘要： The present disclosure provides compositions and methods useful for treating HCMV infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more HCMV epitopes, such as, for example, from HCMV envelope glycoproteins gB and/or gH and/or tegument protein pp65. Among other things, the present invention encompasses the recognition that a combination of antigens (e.g., envelope glycoproteins and structural proteins) can lead to beneficial immune responses, for example that include both a humoral response (e.g., production of neutralizing antibodies) and a cellular response (e.g., T-cell activation).