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公开(公告)号：US20240293759A1
公开(公告)日：2024-09-05
申请号：US18650263
申请日：2024-04-30
申请人： Velico Medical, Inc
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Kyle D. Erickson , Evan P. Ordway , Clair Strohl , Russell Barron
摘要： The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs.
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公开(公告)号：US20240123367A1
公开(公告)日：2024-04-18
申请号：US18097352
申请日：2023-01-16
申请人： Velico Medical, Inc.
摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
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公开(公告)号：US20240102730A1
公开(公告)日：2024-03-28
申请号：US18096645
申请日：2023-01-13
申请人： Velico Medical, Inc.
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Evan P. Ordway , Clair Strohl , Russell Barron
摘要： The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
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公开(公告)号：US20240131446A1
公开(公告)日：2024-04-25
申请号：US18467102
申请日：2023-09-14
申请人： Velico Medical, Inc.
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Evan P. Ordway , Clair Strohl , Russell Barron
CPC分类号： B01D1/18 , C12N5/0634 , F26B3/12 , F26B21/004 , F26B25/06
摘要： The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
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公开(公告)号：US20240091664A1
公开(公告)日：2024-03-21
申请号：US17945129
申请日：2022-09-15
申请人： Velico Medical, Inc.
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Kyle D. Erickson , Evan P. Ordway , Clair Strohl , Russell Barron
摘要： The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs.
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公开(公告)号：US11913723B1
公开(公告)日：2024-02-27
申请号：US18096945
申请日：2023-01-13
申请人： Velico Medical, Inc.
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Evan P. Ordway , Clair Strohl , Russell Barron
摘要： The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
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公开(公告)号：US11913722B1
公开(公告)日：2024-02-27
申请号：US18096645
申请日：2023-01-13
申请人： Velico Medical, Inc.
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Evan P. Ordway , Clair Strohl , Russell Barron
摘要： The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
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公开(公告)号：US20240191943A1
公开(公告)日：2024-06-13
申请号：US18412479
申请日：2024-01-13
申请人： Velico Medical, Inc.
摘要： The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
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公开(公告)号：US11998861B2
公开(公告)日：2024-06-04
申请号：US17945129
申请日：2022-09-15
申请人： Velico Medical, Inc.
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Kyle D. Erickson , Evan P. Ordway , Clair Strohl , Russell Barron
摘要： The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs.
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公开(公告)号：US20240123368A1
公开(公告)日：2024-04-18
申请号：US18097822
申请日：2023-01-17
申请人： Velico Medical, Inc.
发明人： Robert R. Andrews , Herman E. Snyder , William J. Merritt , Evan P. Ordway , Clair Strohl , Qiyong Peter Liu , Jihae Sohn
摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
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