-
公开(公告)号：US20210063411A1
公开(公告)日：2021-03-04
申请号：US17021659
申请日：2020-09-15
发明人： Christopher Bieniarz , Jan Froehlich , Brian Daniel Kelly , Rui Hong , Mark Lefever , Phillip Miller , Hong Wang
摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
-
公开(公告)号：US10883999B2
公开(公告)日：2021-01-05
申请号：US16055046
申请日：2018-08-04
发明人： Rui Hong , Hong Wang , Mark Lefever , Jan Froehlich , Christopher Bieniarz , Brian Daniel Kelly , Phillip Miller
摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
-
公开(公告)号：US12092643B2
公开(公告)日：2024-09-17
申请号：US17021659
申请日：2020-09-15
发明人： Christopher Bieniarz , Jan Froehlich , Brian Daniel Kelly , Rui Hong , Mark Lefever , Phillip Miller , Hong Wang
IPC分类号： G01N33/68
CPC分类号： G01N33/6848
摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
-
公开(公告)号：US20190004061A1
公开(公告)日：2019-01-03
申请号：US16055046
申请日：2018-08-04
发明人： Rui Hong , Hong Wang , Mark Lefever , Jan Froehlich , Christopher Bieniarz , Brian Daniel Kelly , Phillip Miller
摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
-
公开(公告)号：US10078083B2
公开(公告)日：2018-09-18
申请号：US14981181
申请日：2015-12-28
发明人： Rui Hong , Hong Wang , Mark Lefever , Jan Froehlich , Christopher Bieniarz , Brian Daniel Kelly , Phillip Miller
CPC分类号： G01N33/6848 , G01N27/62
摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
-
公开(公告)号：US20160139143A1
公开(公告)日：2016-05-19
申请号：US14981181
申请日：2015-12-28
发明人： Rui Hong , Hong Wang , Mark Lefever , Jan Froehlich , Christopher Bieniarz , Brian Daniel Kelly , Phillip Miller
CPC分类号： G01N33/6848 , G01N27/62
摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.025 秒)
