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公开(公告)号：US10030024B2
公开(公告)日：2018-07-24
申请号：US15081076
申请日：2016-03-25
发明人： Luc J. Farmer , Pierre-Andre Fournier , Stephanie Lessard , Bingcan Liu , Miguel St-Onge , Claudio Sturino , Janek Szychowski , Constantin Yannopoulos , Frederic Vallee , Jean-Eric Lacoste , Julien Martel , Monica Bubenik , Yeeman Ramtohul , Camil Elie Sayegh
IPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.
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公开(公告)号：US09890176B2
公开(公告)日：2018-02-13
申请号：US14206303
申请日：2014-03-12
发明人： Evelyne Dietrich , Carl Poisson , Michel Gallant , Stephanie Lessard , Bingcan Liu , Sanjoy Kumar Das , Yeeman Ramtohul , Thumkunta Jagadeeswar Reddy , Julien Martel , Frederic Vallee , Jean-Francois Lévesque
IPC分类号： C07H15/203 , C07H15/20 , C07H15/207 , C07H15/22 , C07D493/10 , C07H15/18
CPC分类号： C07D493/10 , C07H15/18 , C07H15/20 , C07H15/203 , C07H15/207 , C07H15/22
摘要： The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.
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公开(公告)号：US20190119282A1
公开(公告)日：2019-04-25
申请号：US16013523
申请日：2018-06-20
发明人： Luc J. Farmer , Pierre-Andre Fournier , Stephanie Lessard , Bingcan Liu , Miguel St-Onge , Claudio Sturino , Janek Szychowski , Constantin Yannopoulos , Frederic Vallee , Jean-Eric Lacoste , Julien Martel , Monica Bubenik , Yeeman Ramtohul , Camil Elie Sayegh
IPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.
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4.发明申请公开(公告)号：US20160311825A1
公开(公告)日：2016-10-27
申请号：US15081076
申请日：2016-03-25
发明人： Luc J. Farmer , Pierre-Andre Fournier , Stephanie Lessard , Bingcan Liu , Miguel St-Onge , Claudio Sturino , Janek Szychowski , Constantin Yannopoulos , Frederic Vallee , Jean-Eric Lacoste , Julien Martel , Monica Bubenik , Yeeman Ramtohul , Camil Elie Sayegh
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.
摘要翻译： 其中变量如本文所定义。
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公开(公告)号：US20140274930A1
公开(公告)日：2014-09-18
申请号：US14206303
申请日：2014-03-12
发明人： Evelyne Dietrich , Carl Poisson , Michel Gallant , Stephanie Lessard , Bingcan Liu , Sanjoy Kumar Das , Yeeman Ramtohul , Thumkunta Jagadeeswar Reddy , Julien Martel , Frederic Vallee , Jean-Francois Lévesque
IPC分类号： C07H15/26 , C07H15/22 , C07D493/10 , C07H15/207
CPC分类号： C07D493/10 , C07H15/18 , C07H15/20 , C07H15/203 , C07H15/207 , C07H15/22
摘要： The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.
摘要翻译： 本发明涉及可用于治疗或预防细菌感染的化合物。 这些化合物具有式I：本发明还提供了制备本文所述化合物的方法。 此外，本发明提供包含本文所述化合物和药学上可接受的载体，佐剂或载体的组合物。 本发明还提供了治疗或预防受试者细菌感染的方法，包括给予受试者有效量的本文所述的化合物或组合物。
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