公开(公告)号：US20160235775A1

公开(公告)日：2016-08-18

申请号：US15140045

申请日：2016-04-27

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeeman K. Ramtohul ,  Sanjoy Kumar Das ,  Caroline Cadilhac ,  Thumkunta Jagadeeswar Reddy ,  Louis Vaillancourt ,  Michel Gallant ,  Bingcan Liu ,  Evelyne Dietrich ,  Frederic Vallee ,  Julien Martel ,  Carl Poisson

IPC: A61K31/7034 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/706 ,  A61K31/7036 ,  A61K31/7028

CPC classification number: C07H7/02 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  C07D309/10 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07H7/04 ,  C07H7/06 ,  C07H15/26 ,  C07H19/02 ,  C07H19/056

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

Abstract translation: 本发明涉及可用于治疗或预防细菌感染的化合物。 这些化合物具有式I：本发明还提供含有化合物的药学上可接受的组合物和使用该组合物治疗细菌感染的方法。 最后，本发明提供了制备本发明化合物的方法。

公开(公告)号：US10030024B2

公开(公告)日：2018-07-24

申请号：US15081076

申请日：2016-03-25

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Luc J. Farmer ,  Pierre-Andre Fournier ,  Stephanie Lessard ,  Bingcan Liu ,  Miguel St-Onge ,  Claudio Sturino ,  Janek Szychowski ,  Constantin Yannopoulos ,  Frederic Vallee ,  Jean-Eric Lacoste ,  Julien Martel ,  Monica Bubenik ,  Yeeman Ramtohul ,  Camil Elie Sayegh

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.

公开(公告)号：US09963478B2

公开(公告)日：2018-05-08

申请号：US15140045

申请日：2016-04-27

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeeman K. Ramtohul ,  Sanjoy Kumar Das ,  Caroline Cadilhac ,  Thumkunta Jagadeeswar Reddy ,  Louis Vaillancourt ,  Michel Gallant ,  Bingcan Liu ,  Evelyne Dietrich ,  Frederic Vallee ,  Julien Martel ,  Carl Poisson

IPC: A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  C07H7/02 ,  C07D405/14 ,  C07D309/10 ,  C07H15/26 ,  C07D409/14 ,  C07H19/056 ,  C07D417/14 ,  C07H7/04 ,  C07H7/06 ,  C07H19/02 ,  C07D413/14 ,  C07D407/14 ,  C07D495/04

CPC classification number: C07H7/02 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  C07D309/10 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07H7/04 ,  C07H7/06 ,  C07H15/26 ,  C07H19/02 ,  C07H19/056

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

公开(公告)号：US10669298B2

公开(公告)日：2020-06-02

申请号：US15945221

申请日：2018-04-04

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeeman K. Ramtohul ,  Sanjoy Kumar Das ,  Caroline Cadilhac ,  Thumkunta Jagadeeswar Reddy ,  Louis Vaillancourt ,  Michel Gallant ,  Bingcan Liu ,  Evelyne Dietrich ,  Frederic Vallee ,  Julien Martel ,  Carl Poisson

IPC: C07H7/02 ,  C07D413/14 ,  C07D407/14 ,  C07D495/04 ,  C07D405/14 ,  C07D309/10 ,  C07D409/14 ,  C07D417/14 ,  C07H7/04 ,  C07H7/06 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/706 ,  C07H15/26 ,  C07H19/056 ,  C07H19/02 ,  A61K31/7064

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

公开(公告)号：US10407414B2

公开(公告)日：2019-09-10

申请号：US15735412

申请日：2016-06-13

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Michel Gallant ,  Jean-Francois Truchon ,  Thumkunta Jagadeeswar Reddy ,  Evelyne Dietrich ,  Louis Vaillancourt ,  Frederic Vallee

IPC: C07D405/06 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  A61P31/04 ,  C07D413/06

Abstract: The compounds represented by Formula (I) or pharmaceutically acceptable salts thereof: with U, W, X, Y, Z, p and ring A as defined in claim 1. Those compounds are useful for the treatment or prevention of bacteria infections. The variables of Formula (I) are as described herein. Pharmaceutically acceptable compositions comprise the compounds of Formula (I) or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carriers, adjuvants, or vehicles. Methods of treating bacteria infections employ such compounds or pharmaceutically acceptable salts thereof.

公开(公告)号：US20180244658A1

公开(公告)日：2018-08-30

申请号：US15735412

申请日：2016-06-13

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Michel Gallant ,  Jean-Francois Truchon ,  Thumkunta Jagadeeswar Reddy ,  Evelyne Dietrich ,  Louis Vaillancourt ,  Frederic Vallee

IPC: C07D405/06 ,  C07D413/06 ,  C07D471/04 ,  C07D413/14 ,  C07D405/14 ,  A61P31/04

CPC classification number: C07D405/06 ,  A61P31/04 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04

Abstract: The compounds represented by Formula (I) or pharmaceutically acceptable salts thereof: with U, W, X, Y, Z, p and ring A as defined in claim 1. Those compounds are useful for the treatment or prevention of bacteria infections. The variables of Formula (I) are as described herein. Pharmaceutically acceptable compositions comprise the compounds of Formula (I) or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carriers, adjuvants, or vehicles. Methods of treating bacteria infections employ such compounds or pharmaceutically acceptable salts thereof.

公开(公告)号：US11634447B2

公开(公告)日：2023-04-25

申请号：US17120441

申请日：2020-12-14

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeeman K. Ramtohul ,  Sanjoy Kumar Das ,  Caroline Cadilhac ,  Thumkunta Jagadeeswar Reddy ,  Louis Vaillancourt ,  Michel Gallant ,  Bingcan Liu ,  Evelyne Dietrich ,  Frederic Vallee ,  Julien Martel ,  Carl Poisson

IPC: A61K31/706 ,  A61K31/7064 ,  C07H7/02 ,  C07D413/14 ,  C07D407/14 ,  C07D495/04 ,  C07D405/14 ,  C07D309/10 ,  C07H15/26 ,  C07D409/14 ,  C07H19/056 ,  C07D417/14 ,  A61P31/04 ,  C07H7/04 ,  C07H7/06 ,  C07H19/02 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7056

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

公开(公告)号：US20220135609A1

公开(公告)日：2022-05-05

申请号：US17120441

申请日：2020-12-14

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeeman K. Ramtohul ,  Sanjoy Kumar Das ,  Caroline Cadilhac ,  Thumkunta Jagadeeswar Reddy ,  Louis Vaillancourt ,  Michel Gallant ,  Bingcan Liu ,  Evelyne Dietrich ,  Frederic Vallee ,  Julien Martel ,  Carl Poisson

IPC: C07H7/02 ,  C07D413/14 ,  C07D407/14 ,  C07D495/04 ,  C07D405/14 ,  C07D309/10 ,  C07H15/26 ,  C07D409/14 ,  C07H19/056 ,  C07D417/14 ,  C07H7/04 ,  C07H7/06 ,  C07H19/02 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

公开(公告)号：US20200270293A1

公开(公告)日：2020-08-27

申请号：US16837191

申请日：2020-04-01

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeeman K. Ramtohul ,  Sanjoy Kumar Das ,  Caroline Cadilhac ,  Thumkunta Jagadeeswar Reddy ,  Louis Vaillancourt ,  Michel Gallant ,  Bingcan Liu ,  Evelyne Dietrich ,  Frederic Vallee ,  Julien Martel ,  Carl Poisson

IPC: C07H7/02 ,  C07D413/14 ,  C07D407/14 ,  C07D495/04 ,  C07D405/14 ,  C07D309/10 ,  C07H15/26 ,  C07D409/14 ,  C07H19/056 ,  C07D417/14 ,  C07H7/04 ,  C07H7/06 ,  C07H19/02 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

公开(公告)号：US09890176B2

公开(公告)日：2018-02-13

申请号：US14206303

申请日：2014-03-12

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Evelyne Dietrich ,  Carl Poisson ,  Michel Gallant ,  Stephanie Lessard ,  Bingcan Liu ,  Sanjoy Kumar Das ,  Yeeman Ramtohul ,  Thumkunta Jagadeeswar Reddy ,  Julien Martel ,  Frederic Vallee ,  Jean-Francois Lévesque

IPC: C07H15/203 ,  C07H15/20 ,  C07H15/207 ,  C07H15/22 ,  C07D493/10 ,  C07H15/18

CPC classification number: C07D493/10 ,  C07H15/18 ,  C07H15/20 ,  C07H15/203 ,  C07H15/207 ,  C07H15/22

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.