公开(公告)号：US20120027816A1

公开(公告)日：2012-02-02

申请号：US13203243

申请日：2010-02-25

申请人： Vijaya Gopal Kusumba ,  Sampath Kumar Sankineni ,  Praveen Kumar Neela ,  Nitin Sharadchandra Pradhan

发明人： Vijaya Gopal Kusumba ,  Sampath Kumar Sankineni ,  Praveen Kumar Neela ,  Nitin Sharadchandra Pradhan

IPC分类号： A61K31/404 ,  A61K9/14 ,  A61P25/30 ,  A61P3/04 ,  A61P25/24 ,  A61P25/06 ,  A61P25/00 ,  A61P29/00 ,  C07D403/06 ,  A61P25/22

CPC分类号： C07D403/06

摘要： Provided herein is an impurity of eletriptan, eletriptan N-oxide, (R)-5-[2- (phenylsulfonypethyl]-3-[(1-methyl-2-pyrrolidinyl-N-oxide)methyl]-1H-indole, and a process for the preparation and isolation thereof. Provided further herein is a highly pure eletriptan or a pharmaceutically acceptable salt thereof substantially free of eletriptan N-oxide impurity, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure eletriptan or a pharmaceutically acceptable salt thereof substantially free of eletriptan N-oxide impurity.

摘要翻译： 本文提供的是伊马替尼，依托曲坦N-氧化物，（R）-5- [2-（苯基磺基丙基）-3 - [（1-甲基-2-吡咯烷基-N-氧化物）甲基] -1H-吲哚的杂质，和 本发明进一步提供了基本上不含依他曲坦N-氧化物杂质的高纯度的伊曲普坦或其药学上可接受的盐，其制备方法和包含高纯度的依他曲坦或其药学上可接受的盐的药物组合物 其基本上不含依他曲坦N-氧化物杂质。

公开(公告)号：US20100285075A1

公开(公告)日：2010-11-11

申请号：US12808762

申请日：2008-12-17

申请人： Vijaya Gopal Kusumba ,  Sampath Kumar Sankineni ,  Praveen Kumar Neela ,  Nitin Sharadchandra Pradhan ,  Jon Valgeirsson

发明人： Vijaya Gopal Kusumba ,  Sampath Kumar Sankineni ,  Praveen Kumar Neela ,  Nitin Sharadchandra Pradhan ,  Jon Valgeirsson

IPC分类号： A61K31/4045 ,  C07D403/06 ,  A61P25/24 ,  A61P25/22 ,  A61P3/00 ,  A61P3/04 ,  A61P25/30 ,  A61P29/00 ,  A61K9/14

CPC分类号： C07D403/06

摘要： The present invention relates to novel hemioxalate salt of eletriptan, process for preparation, pharmaceutical compositions, and method of treating thereof. The present invention relates to solid forms of eletriptan hemioxalate, processes for preparation, pharmaceutical compositions, and method of treating thereof. The solid form of eletriptan hemioxalate is useful for preparing eletriptan free base or a pharmaceutically acceptable salt thereof, particularly eletriptan hydrobromide, in high purity. The present invention also provides a process for preparing substantially pure eletriptan hydrobromide using eletriptan hemioxalate.

摘要翻译： 本发明涉及新颖的依他曲坦半盐酸盐，制备方法，药物组合物及其治疗方法。 本发明涉及依托曲坦半胱氨酸盐的固体形式，其制备方法，药物组合物及其处理方法。 依托曲坦半胱氨酸盐的固体形式可用于以高纯度制备伊曲坦游离碱或其药学上可接受的盐，特别是依托曲坦氢溴酸盐。 本发明还提供了使用依他曲坦半胱氨酸盐制备基本上纯的依他曲坦氢溴酸盐的方法。