-
公开(公告)号：US06670370B1
公开(公告)日：2003-12-30
申请号：US10281725
申请日：2002-10-28
IPC分类号： A61K31485
CPC分类号： A61K31/4402 , C07D213/38 , Y10S514/85 , Y10S514/855
摘要： The invention pertains to a composition comprising dextromethorphan tannate and to a method for preparing dextromethorphan tannate by reacting dextromethorphan at a temperature of about 80 to about 180° C. with tannic acid either neat or as an aqueous slurry containing about 5 to about 30 wt. % water. The dextromethorphan tannate has extended release properties and is useful in pharmaceutical compositions as an antitussive for human beings.
摘要翻译： 本发明涉及包含右美沙芬丹宁酸盐的组合物和通过使右美沙芬在约80至约180℃的温度下反应制备右美沙芬来制备右美沙芬的方法，所述丹宁酸是纯的或含有约5至约30wt。 ％ 水。 右美沙芬丹宁酸盐具有延长的释放性能，并且可用作药物组合物作为人类镇咳药。
-
公开(公告)号：US06455727B1
公开(公告)日：2002-09-24
申请号：US10017136
申请日：2001-12-14
IPC分类号： C07C6988
CPC分类号： C07C213/08 , C07C2601/08 , C07C217/08
摘要： The invention pertains to a process for preparing carbetapentane tannate. The process involves the steps of heating carbetapentane to a temperature of about 80 to about 120° C. and slowly adding tannic acid to the carbetapentane while agitating the reaction mixture. Preferably, no water or any other solvent or diluent is utilized in the process.
摘要翻译： 本发明涉及制备十八烷酸萘甲酯的方法。 该方法包括加热碳代戊烷至约80至约120℃的温度并在搅拌反应混合物的同时缓慢加入单宁酸至碳氮杂环丁烷的步骤。 优选地，在该方法中不使用水或任何其它溶剂或稀释剂。
-
3.发明授权公开(公告)号：US07388001B1
公开(公告)日：2008-06-17
申请号：US11223687
申请日：2005-09-09
CPC分类号： C07H5/04 , A61K9/19 , A61K9/5031 , A61K31/70
摘要： Glucosamine sulfate having a purity of at least about 99 wt. %, and a maximum halide content of about 0.01 wt. %. Preferably, the glucosamine sulfate is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers; polypropylene glycol homopolymers and copolymers; ethylcellulose; povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated glucosamine sulfate composition will be stable at ambient temperatures and upon exposure to the atmosphere.
摘要翻译： 具有至少约99重量％的纯度的硫酸葡萄糖胺 ％，最大卤化物含量为约0.01wt。 ％。 优选地，硫酸葡糖胺通过用包含水溶性，水不混溶和/或水可溶胀的均聚物和/或共聚物的至少一种药学上可接受的聚合物进行包衣来稳定。 合适的聚合物包括羧基聚亚甲基均聚物和共聚物; 聚乙二醇均聚物和共聚物; 聚丙二醇均聚物和共聚物; 乙基纤维素; 聚维酮均聚物和共聚物; 聚丙烯酸均聚物和共聚物; 聚丙烯酰胺均聚物和共聚物; 多糖; 以及两种或更多种上述聚合物的混合物。 所得的包被的硫酸葡萄糖胺组合物在环境温度下和暴露于大气中时将是稳定的。
-
-
搜索结果
3 条记录 (耗时 0.015 秒)