-
公开(公告)号：US06642417B2
公开(公告)日：2003-11-04
申请号：US09766987
申请日：2001-01-22
Applicant: Vinh D. Tran , Vu Van Ma , Ruiyan Liu
Inventor： Vinh D. Tran , Vu Van Ma , Ruiyan Liu
IPC: C07C23304
CPC classification number: C40B80/00 , C07B2200/11 , C07C59/74 , C07C205/37 , C07C205/44 , C07C235/06
Abstract: A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R1 is —NO2 or —CHO; R2 is —OCH3, —CHO or —H; R3 is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n=1 or 3-12. A substrate of solid phase synthesis of the formula III is also disclosed.
Abstract translation: 公开了一种用于固相合成的底物，其包含式I的固相 - 连接体组合。 还公开了制备基材和其中有用的化学中间体的方法。 其中新的中间体是式II化合物，其中R 1是-NO 2或-CHO; R 2是-OCH 3，-CHO或-H; R 3选自羟基，具有多个氨基的固体支持物的残基和酯的残基，n = 1或3-12。A的固相合成底物 还公开了式III。
-
公开(公告)号：US06310244B1
公开(公告)日：2001-10-30
申请号：US09121262
申请日：1998-07-23
Applicant: Vinh D. Tran , Vu Van Ma , Ruiyan Liu
Inventor： Vinh D. Tran , Vu Van Ma , Ruiyan Liu
IPC: C07C23304
CPC classification number: C40B80/00 , C07B2200/11 , C07C59/74 , C07C205/37 , C07C205/44 , C07C235/06
Abstract: A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R1 is —NO2 or —CHO; R2 is —OCH3, —CHO or —H; R3 is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n=1 or 3. A substrate of solid phase synthesis of the formula III is also disclosed.
Abstract translation: 公开了一种用于固相合成的底物，其包含式I的固相 - 连接体组合。 还公开了制备基材和其中有用的化学中间体的方法。 其中新型中间体为式II化合物，其中R 1为-NO 2或-CHO; R2是-OCH3，-CHO或-H; R3选自羟基，具有多个氨基的固体支持物的残基和酯的残基，n = 1或3.还公开了式III的固相合成底物 。
-
公开(公告)号：US07511049B2
公开(公告)日：2009-03-31
申请号：US11779050
申请日：2007-07-17
Applicant: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhenmin He , Ray Anthony James , Haengsoon Park
Inventor： Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhenmin He , Ray Anthony James , Haengsoon Park
IPC: A61K31/519 , A61P35/00 , C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/52 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Abstract translation: 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。
-
公开(公告)号：US07309705B2
公开(公告)日：2007-12-18
申请号：US11395824
申请日：2006-03-31
Applicant: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
Inventor： Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
IPC: A61K31/519 , A61P35/00 , C07D484/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/52 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
-
公开(公告)号：US07161003B1
公开(公告)日：2007-01-09
申请号：US10654546
申请日：2003-09-03
Applicant: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Alan Mallams , Carmen S. Alvarez , Kartik M. Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry O. Fischmann , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park , Vidyadhar M. Paradkar , Douglas Walsh Hobbs
Inventor： Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Alan Mallams , Carmen S. Alvarez , Kartik M. Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry O. Fischmann , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park , Vidyadhar M. Paradkar , Douglas Walsh Hobbs
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Abstract translation: 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。
-
Patent Agency Ranking
公开(公告)号：US07038054B1
公开(公告)日：2006-05-02
申请号：US10166833
申请日：2002-06-11
Applicant: John J. Baldwin , Vinh D. Tran
Inventor： John J. Baldwin , Vinh D. Tran
IPC: C07D471/02
CPC classification number: C07D471/10
Abstract: Diazabicyclononanes of formula I and their synthesis are disclosed. The compounds are useful as scaffolds for constructing combinatorial libraries.
Abstract translation: 公开了式I的二氮杂双环壬烷及其合成。 这些化合物可用作构建组合文库的支架。
-
公开(公告)号：US07084271B2
公开(公告)日：2006-08-01
申请号：US10654163
申请日：2003-09-03
Applicant: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Chad Knutson , Brian McKittrick , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
Inventor： Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Chad Knutson , Brian McKittrick , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
-
8.发明授权N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors 有权N-杂芳基吡唑并嘧啶作为细胞周期蛋白依赖性激酶抑制剂公开(公告)号：US07807683B2
公开(公告)日：2010-10-05
申请号：US11396001
申请日：2006-03-31
Applicant: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Alan Mallams , Carmen S. Alvarez , Kartik M. Keertikar , Jocelyn Rivera , Tin Yau Chan , Vincent Madison , Thierry O. Fischmann , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park , Vidyadhar M. Paradkar , Douglas Walsh Hobbs
Inventor： Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Alan Mallams , Carmen S. Alvarez , Kartik M. Keertikar , Jocelyn Rivera , Tin Yau Chan , Vincent Madison , Thierry O. Fischmann , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park , Vidyadhar M. Paradkar , Douglas Walsh Hobbs
IPC: A61K31/519 , A61P35/04 , A61P35/02 , C07D487/04 , A61P35/00
CPC classification number: C07D487/04
Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Abstract translation: 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。
-
9.发明授权N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors 有权N-杂芳基吡唑并嘧啶作为细胞周期蛋白依赖性激酶抑制剂公开(公告)号：US07470695B2
公开(公告)日：2008-12-30
申请号：US11395974
申请日：2006-03-31
Applicant: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
Inventor： Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
IPC: C07D487/04 , A61K31/519 , A61P35/04
CPC classification number: C07D487/04
Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Abstract translation: 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。
-
公开(公告)号：US07078525B2
公开(公告)日：2006-07-18
申请号：US10654157
申请日：2003-09-03
Applicant: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
Inventor： Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
-
-
-
-
-
-
-
-
-
Search Results
16
records
(took 0.04 seconds)
