公开(公告)号：US11760748B2

公开(公告)日：2023-09-19

申请号：US18080570

申请日：2022-12-13

申请人： Viracta Subsidiary, Inc.

发明人： Xiaohu Deng ,  Wanping Mai ,  Robert Mcrae ,  Biljana Nadjsombati

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/522

CPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/522 ,  C07B2200/13

摘要： The present disclosure relates to the crystalline mesylate Form 1 salt of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.0]hex-3-yl}pyrimidine-5-carboxamide and methods of making the same. The crystalline mesylate Form 1 salt of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.0]hex-3-yl}pyrimidine-5-carboxamide is useful in preparation of pharmaceutical compositions and dosage forms for the treatment of cancer, immune disorders and inflammation.

公开(公告)号：US12012396B2

公开(公告)日：2024-06-18

申请号：US18364074

申请日：2023-08-02

申请人： Viracta Subsidiary, Inc.

发明人： Xiaohu Deng ,  Wanping Mai ,  Robert C. McRae ,  Biljana Nadjsombati

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/522

CPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/522 ,  C07B2200/13

摘要： The present disclosure relates to the crystalline mesylate Form 1 salt of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.0]hex-3-yl}pyrimidine-5-carboxamide and methods of making the same. The crystalline mesylate Form 1 salt of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.0]hex-3-yl}pyrimidine-5-carboxamide is useful in preparation of pharmaceutical compositions and dosage forms for the treatment of cancer, immune disorders and inflammation.

公开(公告)号：US11780822B2

公开(公告)日：2023-10-10

申请号：US18080566

申请日：2022-12-13

申请人： Viracta Subsidiary, Inc.

发明人： Xiaohu Deng ,  Stewart Jones ,  David Slack

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  C07B2200/13

摘要： The present disclosure relates to various solid-state forms of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.0]hex-3-yl}pyrimidine-5-carboxamide and methods of making the same. Such forms of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.0]hex-3-yl}pyrimidine-5-carboxamide are useful in preparation of pharmaceutical compositions and dosage forms for the treatment of cancer, immune disorders and inflammation.