公开(公告)号：US20220081425A1

公开(公告)日：2022-03-17

申请号：US17478187

申请日：2021-09-17

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION

Inventor： Juan WANG ,  Hu YANG

IPC: C07D405/06 ,  A61P27/06 ,  A61K9/00 ,  A61K31/4178 ,  A61K45/06

Abstract: The present disclosure provides pilocarpine ionic liquid analogs useful in the treatment of ophthalmological disorders such as glaucoma.

公开(公告)号：US20210154202A1

公开(公告)日：2021-05-27

申请号：US17048586

申请日：2019-04-16

Applicant: Virginia Commonwealth University

Inventor： Michael LANCINA ,  Juan WANG ,  Hu YANG

IPC: A61K31/5377 ,  A61K47/60 ,  A61K47/59 ,  A61K47/61 ,  A61K9/00 ,  A61P27/06

Abstract: Compounds, comprising a selective β-blocker coupled to a PAMAM dendrimer via a flexible spacer, and compositions containing the compounds, are provided. Methods of making and using the compounds and compositions for the treatment of glaucoma and other maladies are also provided.

公开(公告)号：US20220010076A1

公开(公告)日：2022-01-13

申请号：US17297853

申请日：2019-11-27

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Boxuan LI ,  Juan WANG ,  Hu YANG

IPC: C08J3/05 ,  A61K47/36 ,  C08L5/08 ,  A61K8/73 ,  A23L29/275

Abstract: A method is provided for producing a composition comprising chitosan and water, comprising dissolving chitosan powder in an ionic liquid, to prepare a first composition comprising chitosan and ionic liquid; and contacting the first composition with water under conditions sufficient to solvent-exchange all or substantially all of the ionic liquid with water; to form a composition comprising chitosan and water. Compositions produced thereby and methods of using the compositions are provided.