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公开(公告)号：US20070293476A1
公开(公告)日：2007-12-20
申请号：US11750579
申请日：2007-05-18
IPC分类号： A61K31/55 , A61K31/454 , A61K31/405 , A61K31/4025 , A61K31/381 , A61K31/343
CPC分类号： A61K45/06 , A61K31/381
摘要： The present invention is directed to a method for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-heteroaryl sulfamide derivative as described herein and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
摘要翻译： 本发明涉及治疗癫痫和相关病症的方法，其包括向有需要的受试者施用治疗有效量的如本文所述的苯并杂芳基磺酰胺衍生物和治疗有效量的一种 或更多抗惊厥药和/或抗癫痫剂。
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2.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF DEPRESSION 审中-公开苯并呋喃磺酰胺衍生物用于治疗呕吐的应用公开(公告)号：US20070155827A1
公开(公告)日：2007-07-05
申请号：US11612249
申请日：2006-12-18
IPC分类号： A61K31/36 , A61K31/353
CPC分类号： A61K31/353 , A61K31/352 , A61K31/357
摘要： The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment of depression, which includes mono-therapy and alternatively, co-therapy with at least one antidepressant.
摘要翻译： 本发明是一种治疗抑郁症的方法，包括向有需要的受试者施用治疗有效量的如本文所定义的一种或多种式（I）和式（II）的新型苯并稠合的杂环磺酰胺衍生物。 本发明涉及一种治疗抑郁症的方法，其包括单一治疗，或者与至少一种抗抑郁药共同治疗。
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公开(公告)号：US20060030604A1
公开(公告)日：2006-02-09
申请号：US11236097
申请日：2005-09-27
申请人： Magdalena Elsinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
发明人： Magdalena Elsinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
IPC分类号： C07D285/08 , A61K31/433
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
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4.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION 失效用于治疗物质滥用和添加剂的苯并 - 氟化异硫氰酸酯衍生物的使用公开(公告)号：US20070155825A1
公开(公告)日：2007-07-05
申请号：US11612202
申请日：2006-12-18
IPC分类号： A61K31/36 , A61K31/353
CPC分类号： A61K31/353 , A23V2002/00 , A61K31/357 , A23V2200/334
摘要： The present invention is a method for the treatment of alcohol abuse and/or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and/or formula (II) as herein defined.
摘要翻译： 本发明是用于治疗酒精滥用和/或成瘾的方法，包括向有需要的受试者施用治疗有效量的一种或多种式（I）和/或式（II）的新型苯并稠合的杂环磺酰胺衍生物 ）。
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5.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR LOWERING LIPIDS AND LOWERING BLOOD GLUCOSE LEVELS 失效用于降低脂肪和降低血液葡萄糖水平的苯并稠合的脂质体磺酰胺衍生物公开(公告)号：US20070155821A1
公开(公告)日：2007-07-05
申请号：US11611961
申请日：2006-12-18
IPC分类号： A61K31/335
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357
摘要： The present invention is a method for the glucose related disorders and lipid related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) or formula (II) as herein defined. The present invention is further directed to methods of treatment comprising co-therapy with an anti-diabetic agent, and anti-lipid agent and/or an anti-obesity agent.
摘要翻译： 本发明是一种葡萄糖相关疾病和脂质相关病症的方法，包括向有需要的受试者施用治疗有效量的本文所述的一种或多种式（I）或式（II）的新型苯并稠合的杂环磺酰胺衍生物 定义 本发明进一步涉及包括与抗糖尿病药物和抗脂质剂和/或抗肥胖剂的协同治疗的治疗方法。
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公开(公告)号：US20060128772A1
公开(公告)日：2006-06-15
申请号：US11344772
申请日：2006-02-01
申请人： Magdalena Eisinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D417/12
摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
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7.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY 失效用于治疗肥胖的苯并 - ZO ED LE LE LE LE IDE IDE IDE IDE IDE ITY ITY ITY ITY ITY ITY公开(公告)号：US20080027131A1
公开(公告)日：2008-01-31
申请号：US11611938
申请日：2006-12-18
IPC分类号： A61K31/357 , A61K31/352 , A61P3/04
CPC分类号： A61K31/353 , A61K31/357
摘要： The present invention is a method for the treatment of obesity, for promoting weight loss and/or suppressing appetite comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) as herein defined.
摘要翻译： 本发明是一种治疗肥胖症，促进体重减轻和/或抑制食欲的方法，包括向有需要的受试者施用治疗有效量的一种或多种式（I）的新型苯并稠合的杂环磺酰胺衍生物作为 在此定义。
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公开(公告)号：US20070293440A1
公开(公告)日：2007-12-20
申请号：US11750600
申请日：2007-05-18
IPC分类号： A61K31/7008 , A61K31/5513 , A61K31/55 , A61K31/353 , A61K31/343 , A61K31/515 , A61K31/335 , A61K31/35 , A61K31/36 , A61K31/198
CPC分类号： A61K31/337 , A61K31/18 , A61K45/06 , C07D311/58 , C07D317/46 , C07D317/70 , C07D319/20 , C07D319/22 , C07D321/10 , A61K2300/00
摘要： The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
摘要翻译： 本发明涉及用于治疗癫痫和相关病症的共同治疗，其包括向有需要的受试者施用治疗有效量的苯并稠合的杂环磺酰胺衍生物和治疗有效量的一种或多种 更多的抗惊厥药和/或抗癫痫剂。
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9.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES AS NEUROPROTECTIVE AGENTS 审中-公开苯并ZO ED LE LE LE LE IDE IDE IDE IDE ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS公开(公告)号：US20070155823A1
公开(公告)日：2007-07-05
申请号：US11612146
申请日：2006-12-18
IPC分类号： A61K31/36 , A61K31/335
CPC分类号： A61K31/353 , A61K31/357
摘要： The present invention is a methods for neuroprotection, for treating an acute neurodegenerative disorder, for treating a chronic neurodegenerative disorder and/or for preventing neuron death or damage following brain, head and/or spinal cord trauma or injury comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined.
摘要翻译： 本发明是用于治疗急性神经变性疾病，治疗慢性神经变性疾病和/或预防脑，头部和/或脊髓创伤或损伤后的神经元死亡或损伤的神经保护的方法，包括对需要的受试者施用 其具有治疗有效量的如本文所定义的一种或多种式（I）和式（II）的苯并稠合的杂环磺酰胺衍生物。
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10.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN 失效苯并呋喃磺酰胺衍生物用于治疗疼痛的使用公开(公告)号：US20070155822A1
公开(公告)日：2007-07-05
申请号：US11612071
申请日：2006-12-18
IPC分类号： A61K31/335 , A61K31/36
CPC分类号： A61K31/357 , A61K31/352 , A61K31/353
摘要： The present invention is a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as described herein. The present invention is further directed to methods for the treatment of pain comprising co-therapy with analgesic agent(s) and a compound of formula (I) or formula (II) as described herein.
摘要翻译： 本发明是一种治疗疼痛的方法，包括向有需要的受试者施用治疗有效量的一种或多种如本文所述的式（I）和式（II）的新型苯并稠合的杂环磺酰胺衍生物。 本发明还涉及用于治疗疼痛的方法，其包括与止痛剂和本文所述的式（I）或式（II）化合物的协同治疗。
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