公开(公告)号：US08841281B2

公开(公告)日：2014-09-23

申请号：US13653883

申请日：2012-10-17

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Joseph S. Merola

IPC: A61K31/66 ,  C07D207/00

CPC classification number: C07F15/0033 ,  C07F15/0073 ,  C07F17/02

Abstract: The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.

Abstract translation: 本发明涉及化学和药物领域。 本发明的实施方案提供氨基酸的过渡金属络合物。 根据类别I，II，III和/或IV的本发明的实施方案的过渡金属络合物可以用作抗微生物剂，抗疟剂和抗癌剂以及化学反应中的催化剂。 本发明的这些化合物特别可用于抵抗广泛范围的微生物（如MRSA和分枝杆菌）（包括革兰氏阳性菌和革兰氏阴性细菌）的多药耐药性，并且可用作抗膀胱癌的抗癌剂 ，乳腺癌，结肠癌，直肠癌，子宫内膜癌，肾癌，白血病，肺癌，黑素瘤，非霍奇金淋巴瘤，胰腺癌，前列腺癌和甲状腺癌。

公开(公告)号：US20130096090A1

公开(公告)日：2013-04-18

申请号：US13653883

申请日：2012-10-17

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Joseph S. Merola

IPC: A61K31/28 ,  A61K31/295 ,  A61K31/282 ,  A61K31/555 ,  C07F15/06 ,  C07F15/02 ,  C07F1/12 ,  C07F15/00 ,  C07F1/10 ,  C07F1/08 ,  A61K31/30 ,  A61P31/04 ,  A61P35/00 ,  A01P1/00 ,  A61K31/66 ,  C07F19/00 ,  A01N57/20 ,  A01N55/02

CPC classification number: C07F15/0033 ,  C07F15/0073 ,  C07F17/02

Abstract: The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.

Abstract translation: 本发明涉及化学和药物领域。 本发明的实施方案提供氨基酸的过渡金属络合物。 根据类别I，II，III和/或IV的本发明的实施方案的过渡金属络合物可以用作抗微生物剂，抗疟剂和抗癌剂以及化学反应中的催化剂。 本发明的这些化合物特别可用于抵抗广泛范围的微生物（如MRSA和分枝杆菌），包括革兰氏阳性和革兰氏阴性细菌的多药耐药性，并且可用作抗膀胱癌的抗癌剂 ，乳腺癌，结肠癌，直肠癌，子宫内膜癌，肾癌，白血病，肺癌，黑素瘤，非霍奇金淋巴瘤，胰腺癌，前列腺癌和甲状腺癌。