公开(公告)号：US12091484B2

公开(公告)日：2024-09-17

申请号：US16982536

申请日：2019-03-18

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： John Matson ,  Kyle Arrington ,  Kevin Edgar ,  Junyi Chen

IPC: C08F293/00 ,  C08F290/10 ,  C08L65/00

CPC classification number: C08F293/00 ,  C08F290/10 ,  C08L65/00

Abstract: Described herein are block copolymers that can be used as compatibilizers. The block copolymers can be graft block or triblock copolymers. The block copolymers can include a polysaccharide or a polyester and a polyolefin. Also described herein are polymer blends that can include and be made using the block copolymers described herein.

公开(公告)号：US20220298265A1

公开(公告)日：2022-09-22

申请号：US17836338

申请日：2022-06-09

Applicant: Virginia Tech Intellectual Properties, Inc. ,  Purdue Research Foundation

Inventor： Kevin J. Edgar ,  Brittany L.B. Nichols ,  Junyi Chen ,  Charles Frazier ,  Lynne S. Taylor ,  Laura I. Mosquera-Giraldo ,  Ann Norris ,  Benjamin Adams

IPC: C08B37/08 ,  C08B37/02 ,  C08B31/18 ,  C08B31/12 ,  C08B11/04 ,  C08J3/24 ,  C08B33/04 ,  C08B11/20

Abstract: A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.

公开(公告)号：US12162962B2

公开(公告)日：2024-12-10

申请号：US17836338

申请日：2022-06-09

Applicant: Virginia Tech Intellectual Properties, Inc. ,  Purdue Research Foundation

Inventor： Kevin J. Edgar ,  Brittany L. B. Nichols ,  Junyi Chen ,  Charles Frazier ,  Lynne S. Taylor ,  Laura I. Mosquera-Giraldo ,  Ann Norris

IPC: C08B37/08 ,  C08B11/04 ,  C08B11/20 ,  C08B31/12 ,  C08B31/18 ,  C08B33/04 ,  C08B37/02 ,  C08J3/24

Abstract: A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.

公开(公告)号：US20250101139A1

公开(公告)日：2025-03-27

申请号：US18974476

申请日：2024-12-09

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Kevin J. Edgar ,  Brittany L.B. Nichols ,  Junyi Chen ,  Charles Frazier ,  Ann Norris

IPC: C08B37/08 ,  C08B11/04 ,  C08B11/20 ,  C08B31/12 ,  C08B31/18 ,  C08B33/04 ,  C08B37/02 ,  C08J3/24

Abstract: A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.