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1.发明申请Acceleration of Joseph's method for full 3D reconstruction of nuclear medical images from projection data 有权加速约瑟夫从投影数据全面3D重建核医学图像的方法公开(公告)号：US20080219525A1
公开(公告)日：2008-09-11
申请号：US11716359
申请日：2007-03-09
CPC分类号： G06T11/005 , A61B6/037
摘要： A method for interpolating at least one oblique line of response ray representing nuclear image projection data through a rectangular volume and a system for using the method. The method consists of steps of interpolating all the direct rays in a rectangular volume, making a projected ray by projecting the oblique ray onto a surface of the rectangular volume, matching the projected ray to a coinciding interpolated direct ray, shearing the rectangular volume to match the projected ray, and interpolating the oblique ray in the sheared volume.
摘要翻译： 一种用于内插通过矩形体积表示核图像投影数据的响应光线的至少一条斜线和用于使用该方法的系统的方法。 该方法包括将所有直射光线插入矩形体积中的步骤，通过将倾斜射线投射到矩形体积的表面上，将投射光线匹配成符合插值的直接射线，将矩形体积剪切成匹配 投射光线，并将剪切光线插入剪切体积。
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2.发明授权Acceleration of Joseph's method for full 3D reconstruction of nuclear medical images from projection data 有权加速约瑟夫从投影数据全面3D重建核医学图像的方法公开(公告)号：US07856129B2
公开(公告)日：2010-12-21
申请号：US11716359
申请日：2007-03-09
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , A61B6/037
摘要： A method for interpolating at least one oblique line of response ray representing nuclear image projection data through a rectangular volume and a system for using the method. The method consists of steps of interpolating all the direct rays in a rectangular volume, making a projected ray by projecting the oblique ray onto a surface of the rectangular volume, matching the projected ray to a coinciding interpolated direct ray, shearing the rectangular volume to match the projected ray, and interpolating the oblique ray in the sheared volume.
摘要翻译： 一种用于内插通过矩形体积表示核图像投影数据的响应光线的至少一条斜线和用于使用该方法的系统的方法。 该方法包括将所有直射光线插入矩形体积中的步骤，通过将倾斜射线投射到矩形体积的表面上，将投射光线匹配成符合插值的直接射线，将矩形体积剪切成匹配 投射光线，并将剪切光线插入剪切体积。
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3.发明申请Discrete axial re-binning of time-of-flight positron emission tomography data 有权飞行时间正电子发射断层扫描数据的离散轴向重新分类公开(公告)号：US20080099686A1
公开(公告)日：2008-05-01
申请号：US11804265
申请日：2007-05-17
IPC分类号： G01T1/166
CPC分类号： G01T1/2985 , A61B6/037
摘要： Axial rebinning methods are provided for 3D time-of-flight (TOF) positron emission tomography (PET), based on 2D data rebinning. Rebinning is performed separately for each axial plane parallel to the axis of the PET scanner. An analytical approach is provided that is based on a consistency condition for TOF-PET data with a gaussian profile. A fully discrete approach is also provided, wherein each 2D TOF-PET data is calculated as a linear combination of 3D TOF-PET data having the same sinogram coordinates s and φ.
摘要翻译： 基于2D数据重组，为3D飞行时间（TOF）正电子发射断层扫描（PET）提供轴向重组方法。 对于平行于PET扫描仪的轴的每个轴向平面分别进行重组。 提供了基于具有高斯分布的TOF-PET数据的一致性条件的分析方法。 还提供了完全离散的方法，其中每个2D TOF-PET数据被计算为具有相同正弦图坐标s和phi的3D TOF-PET数据的线性组合。
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4.发明授权Discrete axial re-binning of time-of-flight positron emission tomography data 有权飞行时间正电子发射断层扫描数据的离散轴向重新分类公开(公告)号：US07848559B2
公开(公告)日：2010-12-07
申请号：US11804265
申请日：2007-05-17
IPC分类号： G06K9/00
CPC分类号： G01T1/2985 , A61B6/037
摘要： Axial rebinning methods are provided for 3D time-of-flight (TOF) positron emission tomography (PET), based on 2D data rebinning. Rebinning is performed separately for each axial plane parallel to the axis of the PET scanner. An analytical approach is provided that is based on a consistency condition for TOF-PET data with a gaussian profile. A fully discrete approach is also provided, wherein each 2D TOF-PET data is calculated as a linear combination of 3D TOF-PET data having the same sinogram coordinates s and φ.
摘要翻译： 基于2D数据重组，为3D飞行时间（TOF）正电子发射断层扫描（PET）提供轴向重组方法。 对于平行于PET扫描仪的轴的每个轴向平面分别进行重组。 提供了基于具有高斯分布的TOF-PET数据的一致性条件的分析方法。 还提供了完全离散的方法，其中每个2D TOF-PET数据被计算为具有相同正弦图坐标s和＆phgr的3D TOF-PET数据的线性组合。
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5.发明申请Generating Attenuation Correction Maps for Combined Modality Imaging Studies and Improving Generated Attenuation Correction Maps Using MLAA and DCC Algorithms 有权使用MLAA和DCC算法生成组合模态成像研究和改进生成的衰减校正图的衰减校正图公开(公告)号：US20140056500A1
公开(公告)日：2014-02-27
申请号：US13970753
申请日：2013-08-20
IPC分类号： G06T11/00
CPC分类号： G06T11/005
摘要： The DCC (Data Consistency Condition) algorithm is used in combination with MLAA (Maximum Likelihood reconstruction of Attenuation and Activity) to generate extended attenuation correction maps for nuclear medicine imaging studies. MLAA and DCC are complementary algorithms that can be used to determine the accuracy of the mu-map based on PET data. MLAA helps to estimate the mu-values based on the biodistribution of the tracer while DCC checks if the consistency conditions are met for a given mu-map. These methods are combined to get a better estimation of the mu-values. In gated MR/PET cardiac studies, the PET data is framed into multiple gates and a series of MR based mu-maps corresponding to each gate is generated. The PET data from all gates is combined. Once the extended mu-map is generated the central region is replaced with the MR based mu-map corresponding to that particular gate. On the other hand, in dynamic PET studies the uptake in the patient's arms reaches a steady state only after the tracer distributes throughout the body. Hence, for dynamic scans, the projection data of all frames is summed and used to generate the MLAA based extended mu-map for all frames.
摘要翻译： DCC（数据一致条件）算法与MLAA（衰减和活动的最大似然重构）结合使用，以产生用于核医学成像研究的扩展衰减校正图。 MLAA和DCC是可以用于基于PET数据确定mu-map精度的互补算法。 MLAA有助于根据示踪剂的生物分布估计μ值，而DCC检查是否满足给定mu-map的一致性条件。 将这些方法组合起来，以便更好地估计μ值。 在门控MR / PET心脏研究中，PET数据被框架成多个门，并且生成与每个门对应的一系列基于MR的mu图。 来自所有门的PET数据被组合。 一旦生成了扩展的mu-map，就将中心区域替换为与该特定门对应的基于MR的mu-map。 另一方面，在动态PET研究中，仅在跟踪器分布在整个身体之后，患者的手臂中的摄取才达到稳定状态。 因此，对于动态扫描，将所有帧的投影数据求和并用于为所有帧生成基于MLAA的扩展mu-map。
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6.发明授权Generating attenuation correction maps for combined modality imaging studies and improving generated attenuation correction maps using MLAA and DCC algorithms 有权生成用于组合模态成像研究的衰减校正图，并使用MLAA和DCC算法改进生成的衰减校正图公开(公告)号：US09053569B2
公开(公告)日：2015-06-09
申请号：US13970753
申请日：2013-08-20
CPC分类号： G06T11/005
摘要： The DCC (Data Consistency Condition) algorithm is used in combination with MLAA (Maximum Likelihood reconstruction of Attenuation and Activity) to generate extended attenuation correction maps for nuclear medicine imaging studies. MLAA and DCC are complementary algorithms that can be used to determine the accuracy of the mu-map based on PET data. MLAA helps to estimate the mu-values based on the biodistribution of the tracer while DCC checks if the consistency conditions are met for a given mu-map. These methods are combined to get a better estimation of the mu-values. In gated MR/PET cardiac studies, the PET data is framed into multiple gates and a series of MR based mu-maps corresponding to each gate is generated. The PET data from all gates is combined. Once the extended mu-map is generated the central region is replaced with the MR based mu-map corresponding to that particular gate. On the other hand, in dynamic PET studies the uptake in the patient's arms reaches a steady state only after the tracer distributes throughout the body. Hence, for dynamic scans, the projection data of all frames is summed and used to generate the MLAA based extended mu-map for all frames.
摘要翻译： DCC（数据一致条件）算法与MLAA（衰减和活动的最大似然重构）结合使用，以产生用于核医学成像研究的扩展衰减校正图。 MLAA和DCC是可以用于基于PET数据确定mu-map精度的互补算法。 MLAA有助于根据示踪剂的生物分布估计μ值，而DCC检查是否满足给定mu-map的一致性条件。 将这些方法组合起来，以便更好地估计μ值。 在门控MR / PET心脏研究中，PET数据被框架成多个门，并且生成与每个门对应的一系列基于MR的mu图。 来自所有门的PET数据被组合。 一旦生成了扩展的mu-map，就将中心区域替换为与该特定门对应的基于MR的mu-map。 另一方面，在动态PET研究中，仅在跟踪器分布在整个身体之后，患者的手臂中的摄取才达到稳定状态。 因此，对于动态扫描，将所有帧的投影数据求和并用于为所有帧生成基于MLAA的扩展mu-map。
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7.发明申请Extension of Truncated CT Images For Use With Emission Tomography In Multimodality Medical Images 有权在多模态医学图像中使用截断CT图像用于放射断层扫描的扩展公开(公告)号：US20120155736A1
公开(公告)日：2012-06-21
申请号：US13400322
申请日：2012-02-20
申请人： David D. Faul , Christian J. Michel
发明人： David D. Faul , Christian J. Michel
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/5235 , A61B6/5241 , G06T11/008
摘要： An apparatus and method for expanding the FOV of a truncated computed tomography (CT) scan. An iterative calculation is performed on the original CT image to produce an estimate of the image. The calculated estimate of the reconstructed image includes the original image center and a estimate of the truncated portion outside the image center. The calculation uses an image mask with the image center as one boundary.
摘要翻译： 一种用于扩展截断计算机断层摄影（CT）扫描的FOV的装置和方法。 对原始CT图像进行迭代计算以产生图像的估计。 所计算的重建图像的估计包括原始图像中心和图像中心外的截断部分的估计。 该计算使用图像中心作为一个边界的图像蒙版。
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8.发明申请公开(公告)号：US20120148138A1
公开(公告)日：2012-06-14
申请号：US13400314
申请日：2012-02-20
申请人： David D. Faul , Christian J. Michel
发明人： David D. Faul , Christian J. Michel
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/5235 , A61B6/5241 , G06T11/008
摘要： An apparatus and method for expanding the FOV of a truncated computed tomography (CT) scan. An iterative calculation is performed on the original CT image to produce an estimate of the image. The calculated estimate of the reconstructed image includes the original image center and a estimate of the truncated portion outside the image center. The calculation uses an image mask with the image center as one boundary.
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9.发明申请Co-Registering Attenuation Data and Emission Data in Combined Magnetic Resonance/Positron Emission Tomography (MR/PET) Imaging Apparatus 有权联合磁共振/正电子发射断层扫描（MR / PET）成像仪共同记录衰减数据和排放数据公开(公告)号：US20100074501A1
公开(公告)日：2010-03-25
申请号：US12564685
申请日：2009-09-22
CPC分类号： G01R33/481
摘要： A method for co-registering attenuation data of MR coils in a MR/PET imaging system with PET emission data includes computing a likelihood of PET emission data on a grid in a parameter space based on an algorithm, wherein the algorithm defines L(λ, μbody, μcoils{p}) as a log-likelihood of measured PET data, where λ is an emitter distribution (image), μbody is a known linear attenuation coefficient (LAC) distribution of the body from MRI, μcoils is a linear attenuation coefficient map of MRI coils, and {p} is a set of parameters governing the position of each coil, wherein if μcoils is assumed, then λ can be reconstructed and forward projected and L can be computed. The method includes adjusting the estimated position of the MR coils to maximize the likelihood of emission data based on the computed L.
摘要翻译： 在具有PET发射数据的MR / PET成像系统中共同记录MR线圈的衰减数据的方法包括基于算法计算参数空间中的网格上的PET发射数据的可能性，其中所述算法定义L（λ， μbody，μcoils{p}）作为测量PET数据的对数似然度，其中λ是发射体分布（图像），μbody是来自MRI的身体的已知线性衰减系数（LAC）分布，μ线圈是线性衰减系数 MRI线圈图，{p}是控制每个线圈位置的一组参数，其中如果假设为μcoils，则可以重建λ并且向前投影，并且可以计算L。 该方法包括调整MR线圈的估计位置，以使基于计算出的L的发射数据的可能性最大化。
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10.发明授权Completion of truncated attenuation maps using maximum likelihood estimation of attenuation and activity (MLAA) 有权使用衰减和活动的最大似然估计（MLAA）完成截断的衰减图公开(公告)号：US08620053B2
公开(公告)日：2013-12-31
申请号：US12939701
申请日：2010-11-04
申请人： Christian J. Michel , Johan Nuyts
发明人： Christian J. Michel , Johan Nuyts
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T2211/432
摘要： The present invention is a method of generating a best estimate of an image attenuation map derived from a truncated image attenuation map and PET emissions data for the object being imaged by a morphological imaging modality. The method involves a plurality of steps beginning with the recordation and processing of PET emissions data. Next, the morphological imaging modality records image data which is processed to determine an attenuation map. The attenuation map, for image modalities such as CT and MR scanning systems integrated with PET, is truncated, resulting in a truncated attenuation map image. Pixels for which attenuation data needs to be determined are identified and attenuation coefficients for these pixels are estimated and combined with the truncated attenuation map to generate a full initial attenuation map for the image, which is iteratively processed together with the PET emission data until the improvement change in the emission image reaches a defined threshold improvement level.
摘要翻译： 本发明是一种通过截面图像衰减图导出的图像衰减图的最佳估计和通过形态成像模态成像的对象的PET发射数据的方法。 该方法涉及从记录和处理PET发射数据开始的多个步骤。 接下来，形态学成像模式记录被处理以确定衰减图的图像数据。 对于与PET集成的CT和MR扫描系统的图像模态的衰减图被截断，导致截断的衰减图图像。 识别需要确定衰减数据的像素，并估计这些像素的衰减系数并与截断的衰减图组合，以生成图像的完整初始衰减图，该图再次与PET发射数据一起处理，直到改进 发射图像的变化达到定义的阈值提高水平。
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