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    Stablized Pharmaceutical Composition Comprising an Amorphous Active Substance
    5.
    发明申请
    Stablized Pharmaceutical Composition Comprising an Amorphous Active Substance 审中-公开
    包含无定形活性物质的稳定药物组合物

    公开(公告)号：US20090012150A1

    公开(公告)日：2009-01-08

    申请号：US11923059

    申请日：2007-10-24

    申请人： Rok Grahek ,  Andrej Bastarda ,  Mateja Salobir

    发明人： Rok Grahek ,  Andrej Bastarda ,  Mateja Salobir

    IPC分类号： A61K31/40

    CPC分类号： A61K31/40 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054

    摘要： The invention relates to the pharmaceutical composition comprising the amorphous active substance which is atorvastatin calcium. The process of stabilization of the pharmaceutical composition comprising the pharmaceutical formulation with amorphous atorvastatin calcium, the process of stabilization of the pharmaceutical formulation comprising amorphous atorvastatin calcium and the process of stabilization of atorvastatin calcium in an amorphous form is described.

    摘要翻译： 本发明涉及包含阿托伐他汀钙的无定形活性物质的药物组合物。 描述了包含药物制剂与无定形阿托伐他汀钙的药物组合物的稳定化过程，包含无定形阿托伐他汀钙的药物制剂的稳定化过程和以无定形形式稳定阿托伐他汀钙的方法。

    ACTIVE PHARMACEUTICAL INGREDIENT ADSORBED ON SOLID SUPPORT
    7.
    发明申请
    ACTIVE PHARMACEUTICAL INGREDIENT ADSORBED ON SOLID SUPPORT 审中-公开
    活性药物成分在固体支持剂上的吸附

    公开(公告)号：US20120088774A1

    公开(公告)日：2012-04-12

    申请号：US13263051

    申请日：2010-04-06

    申请人： Rok Grahek ,  Andrej Bastarda ,  Miha T. Jaklic ,  Klemen Kocevar ,  Samo Pirc

    发明人： Rok Grahek ,  Andrej Bastarda ,  Miha T. Jaklic ,  Klemen Kocevar ,  Samo Pirc

    IPC分类号： A61K31/4985 ,  A61P31/18 ,  A61P15/00 ,  A61P9/00 ,  A61K31/351 ,  A61K31/216

    CPC分类号： A61K9/143 ,  A61K9/2009

    摘要： The present invention belongs to the field of pharmaceutical industry and relates to dosage forms comprising active pharmaceutical ingredients (API) such as tadalafil, simvastatin, fenofibrate and lovastatin that are practically insoluble in water, adsorbed on a carrier. Furthermore it relates to an adsorbate comprising API being practically insoluble in water and to a process for the preparation of said adsorbate with non-polar solvent (s) such as chlorinated hydrocarbon, diisopropylethes and hexane. Furthermore the invention relates to a process for the preparation of the dosage form, as well as to the use of the adsorbate for the preparation of the dosage form. Moreover it relates to the dosage form for use in the treatment of erectile dysfunction, human immunodeficiency virus (HIV) infections and/or Acquired Immune Deficiency Syndrome (AIDS).

    摘要翻译： 本发明属于制药工业领域，涉及包含吸附在载体上的实际上不溶于水的活性药物成分（API）如他达拉非，辛伐他汀，非诺贝特和洛伐他汀的剂型。 此外，它涉及包含几乎不溶于水的API的吸附物以及用非极性溶剂如氯化烃，二异丙基醚和己烷制备所述被吸附物质的方法。 此外，本发明涉及制备剂型的方法，以及使用被吸附物来制备剂型。 此外，它涉及用于治疗勃起功能障碍，人类免疫缺陷病毒（HIV）感染和/或获得性免疫缺陷综合征（AIDS）的剂型。