公开(公告)号：US20220339270A1

公开(公告)日：2022-10-27

申请号：US17607141

申请日：2020-04-29

申请人： Voyager Therapeutics, Inc.

发明人： Wencheng Liu ,  Todd Carter ,  Jinzhao Hou ,  Yanqun Shu ,  Giridhar Murlidharan ,  Martin Goulet ,  Dinah Wen-Yee Sah ,  Steven Paul ,  Xiao-Qin Ren ,  Xin Wang ,  Hiu Yan Chung

IPC分类号： A61K39/00 ,  A61P25/28 ,  C12N7/00 ,  C12N15/86

摘要： The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

公开(公告)号：US20230192830A1

公开(公告)日：2023-06-22

申请号：US18046293

申请日：2022-10-13

申请人： VOYAGER THERAPEUTICS, INC.

发明人： Todd Carter ,  Jinzhao Hou ,  Vinodhbabu Kurella ,  Allan D. Capili ,  Wencheng Liu ,  Hiu Yan Chung ,  Jerrah Holth ,  Dillon Kavanagh ,  Maneesha Anand Paranjpe

IPC分类号： C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61P25/28

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/28 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/622

摘要： The present disclosure provides anti-tau antibodies and vectorization thereof (e.g., into AAV particles). Also provided are methods of using anti-tau antibodies and/or AAV particles for prevention, treatment, and/or diagnosis of neurological indications.