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公开(公告)号：US20210371470A1
公开(公告)日：2021-12-02
申请号：US17284499
申请日：2019-10-11
发明人： Giridhar Murlidharan , Dinah Wen-Yee Sah , Holger Patzke , Todd Carter , Jinzhao Hou , Kei Adachi , Amy Ren
IPC分类号： C07K14/005 , C12N7/00 , C12N15/113 , A61P25/28 , A61K9/00 , C12N15/86
摘要： The disclosure provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.
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公开(公告)号：US20240059766A1
公开(公告)日：2024-02-22
申请号：US18267711
申请日：2021-12-15
发明人： Vinodhbabu Kurella , Li Liu , Dillon Kavanagh , Allan D. Capili , Jinzhao Hou , Todd Carter , Wencheng Liu
CPC分类号： C07K16/18 , A61P25/28 , C12N15/63 , C07K2317/14 , C07K2317/31 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides anti-tau antibodies. Also provided are methods of using anti-tau antibodies for treatment and diagnosis of neurological indications.
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公开(公告)号：US20230192830A1
公开(公告)日：2023-06-22
申请号：US18046293
申请日：2022-10-13
发明人： Todd Carter , Jinzhao Hou , Vinodhbabu Kurella , Allan D. Capili , Wencheng Liu , Hiu Yan Chung , Jerrah Holth , Dillon Kavanagh , Maneesha Anand Paranjpe
IPC分类号： C07K16/18 , A61K39/395 , A61K45/06 , A61P25/28
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61P25/28 , A61K2039/505 , C07K2317/14 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/92 , C07K2317/565 , C07K2317/622
摘要： The present disclosure provides anti-tau antibodies and vectorization thereof (e.g., into AAV particles). Also provided are methods of using anti-tau antibodies and/or AAV particles for prevention, treatment, and/or diagnosis of neurological indications.
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公开(公告)号：US20230075314A1
公开(公告)日：2023-03-09
申请号：US17607213
申请日：2020-04-29
发明人： Jinzhao Hou , Yanqun Shu , Todd Carter , Dinah Wen-Yee Sah , Po-Jen Yen , Donna T. Ward , Johanna L. Crimins
IPC分类号： C12N15/86 , C12N15/113 , C07K16/00
摘要： The present disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
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公开(公告)号：US20220339270A1
公开(公告)日：2022-10-27
申请号：US17607141
申请日：2020-04-29
发明人： Wencheng Liu , Todd Carter , Jinzhao Hou , Yanqun Shu , Giridhar Murlidharan , Martin Goulet , Dinah Wen-Yee Sah , Steven Paul , Xiao-Qin Ren , Xin Wang , Hiu Yan Chung
摘要： The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
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公开(公告)号：US20210355454A1
公开(公告)日：2021-11-18
申请号：US17262271
申请日：2019-07-24
发明人： Jacob J. Cardinal , Robert Steininger , Lori B. Karpes , Christopher J. Morrison , Daniel S. Hurwit , Matthew Luther , Andrew M. Wood , Dinah Wen-Yee Sah , Pengcheng Zhou , Jeffrey S. Thompson , Christina Gamba-Vitalo , Jenna Carroll Soper , Steven M. Hersch , Todd Carter
摘要： The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles and AAV formulations, including recombinant adeno-associated virus (rAAV) particles and formulations. In certain embodiments, the present disclosure presents methods and systems for clarifying, purifying, formulating, filtering and processing AAV particles and AAV formulations. The present disclosure also describes compositions, methods and processes for the design, preparation, manufacture, use and/or formulation of AAV particles comprising modulatory polynucleotides, e.g., polynucleotides encoding small interfering RNA (siRNA) molecules which target the Huntingtin (HTT) gene (e.g., the wild-type or the mutated CAG-expanded HTT gene). Methods for using formulated AAV particles comprising modulatory polynucleotides to inhibit the HTT gene expression in a subject with a neurodegenerative disease (e.g., Huntington's Disease (HD)) are also disclosed.
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公开(公告)号：US20210230632A1
公开(公告)日：2021-07-29
申请号：US17055416
申请日：2019-05-15
IPC分类号： C12N15/86 , C12N7/00 , A61P25/28 , A61K9/00 , C12N15/113
摘要： The disclosure provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.
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公开(公告)号：US20210163985A1
公开(公告)日：2021-06-03
申请号：US16636094
申请日：2018-08-03
发明人： Dinah Wen-Yee Sah , Holger Patzke , Jinzhao Hou , Mathieu E. Nonnenmacher , Martin Goulet , Todd Carter
IPC分类号： C12N15/86 , C12N7/00 , A61K9/00 , C07K14/005
摘要： The invention provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.
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公开(公告)号：US20240000971A1
公开(公告)日：2024-01-04
申请号：US18035236
申请日：2021-11-03
发明人： Todd Carter , Wencheng Liu , Jerrah Holth , Jinzhao Hou , Yanqun Shu , Giridhar Murlidharan , Xiao-Qin Ren
CPC分类号： A61K48/0058 , C12N15/86 , A61K48/0066 , A61P25/28 , C07K16/18
摘要： The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
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公开(公告)号：US11512327B2
公开(公告)日：2022-11-29
申请号：US16636094
申请日：2018-08-03
发明人： Dinah Wen-Yee Sah , Holger Patzke , Jinzhao Hou , Mathieu E. Nonnenmacher , Martin Goulet , Todd Carter
IPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , A61K9/00
摘要： The invention provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.
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