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公开(公告)号：US06352692B1
公开(公告)日：2002-03-05
申请号：US09226585
申请日：1999-01-06
IPC分类号： A61K3174
CPC分类号： A61K31/00 , Y10S514/909
摘要： The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
摘要翻译： 本发明的特征在于通过向患者施用已经被一种或多种抑制脂肪酶的基团取代的聚合物来治疗患者的肥胖的方法，脂肪酶是负责脂肪水解的酶。 本发明还涉及本文所述方法中使用的聚合物以及新型中间体和制备聚合物的方法。
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公开(公告)号：US06875428B2
公开(公告)日：2005-04-05
申请号：US10359458
申请日：2003-02-05
CPC分类号： A61K31/00 , Y10S514/909
摘要： The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
摘要翻译： 本发明的特征在于通过向患者施用已经被一种或多种抑制脂肪酶的基团取代的聚合物来治疗患者的肥胖的方法，脂肪酶是负责脂肪水解的酶。 本发明还涉及本文所述方法中使用的聚合物以及新型中间体和制备聚合物的方法。
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公开(公告)号：US06558657B1
公开(公告)日：2003-05-06
申请号：US09714541
申请日：2000-11-16
IPC分类号： A61K3174
CPC分类号： A61K31/00 , Y10S514/909
摘要： The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
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公开(公告)号：US06267952B1
公开(公告)日：2001-07-31
申请号：US09166510
申请日：1998-10-05
IPC分类号： A61K3174
CPC分类号： A61K31/00 , Y10S514/909
摘要： The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
摘要翻译： 本发明的特征在于通过向患者施用已经被一种或多种抑制脂肪酶的基团取代的聚合物来治疗患者的肥胖的方法，脂肪酶是负责脂肪水解的酶。 本发明还涉及本文所述方法中使用的聚合物以及新型中间体和制备聚合物的方法。
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公开(公告)号：US06572850B1
公开(公告)日：2003-06-03
申请号：US09714327
申请日：2000-11-16
IPC分类号： A61K3174
CPC分类号： A61K31/00 , Y10S514/909
摘要： The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
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公开(公告)号：US06299868B1
公开(公告)日：2001-10-09
申请号：US09353329
申请日：1999-07-14
申请人： Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
发明人： Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
IPC分类号： A61K31795
CPC分类号： A61K45/06 , A61K31/785 , A61K2300/00
摘要： The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.
摘要翻译： 本发明涉及一种治疗肥胖症的方法，一种减少膳食脂肪吸收的方法，以及用于治疗患者中的高甘油三酯血症的方法以及用于该方法或用于制备药物的具体聚合物。 所述方法包括向哺乳动物（例如人）口服施用治疗有效量的一种或多种脂肪结合聚合物的步骤。 本发明的脂肪结合聚合物的施用有利于在消化之前从身体去除脂肪，具有最小的副作用和低毒性。 在一个优选的实施方案中，一种或多种脂肪结合聚合物与一种或多种脂肪酶抑制剂，例如脂抑素和四氢脂抑素组合施用。
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公开(公告)号：US07048917B1
公开(公告)日：2006-05-23
申请号：US09721291
申请日：2000-11-22
申请人： Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
发明人： Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
IPC分类号： A61K31/795 , A61K31/785 , A61K31/74
CPC分类号： A61K31/74 , A61K31/785 , A61K31/795 , Y10S514/909
摘要： The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.
摘要翻译： 本发明涉及一种治疗肥胖症的方法，一种减少膳食脂肪吸收的方法，以及用于治疗患者中的高甘油三酯血症的方法以及用于该方法或用于制备药物的具体聚合物。 所述方法包括向哺乳动物（例如人）口服施用治疗有效量的一种或多种脂肪结合聚合物的步骤。 本发明的脂肪结合聚合物的施用有利于在消化之前从身体去除脂肪，具有最小的副作用和低毒性。 在一个优选的实施方案中，一种或多种脂肪结合聚合物与一种或多种脂肪酶抑制剂，例如脂抑素和四氢脂抑素组合施用。
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公开(公告)号：US5700458A
公开(公告)日：1997-12-23
申请号：US717264
申请日：1996-09-20
IPC分类号： C07H15/04 , A61K31/785 , C08F12/14 , C08F16/26 , C08F20/26 , C08F20/28 , C08F20/38 , C08F20/58 , C08F26/02 , C08F220/56 , A61K31/765
CPC分类号： A61K31/785 , C08F20/28 , C08F20/38 , C08F20/58
摘要： The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more acid-functionalized glycoside moieties, such as pendant acid-functionalized glycoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotaviral infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer which comprises an acid-functionalized glycoside-bearing monomer and acrylamide.
摘要翻译： 本发明包括包含酸官能化的糖苷部分的可聚合单体。 在一个实施方案中，单体具有可聚合官能团，例如烯键，酸官能化糖苷部分通过间隔基团连接到其上，例如亚烷基或其中一个或多个碳原子 被杂原子，如氧，氮或硫原子所取代。 本发明还包括可以抑制或预防哺乳动物轮状病毒感染的一种或多种酸官能化糖苷部分的聚合物，例如侧酸官能化糖苷部分。 这样的聚合物可以包括例如本发明的单体。 聚合物可以是均聚物或共聚物，并且可以具有例如聚丙烯酰胺，聚丙烯酸酯或聚苯乙烯主链。 在另一个实施方案中，本发明包括通过向哺乳动物施用治疗有效量的包含一个或多个糖苷部分的聚合物，例如侧链糖苷部分，来治疗哺乳动物例如人类的轮状病毒感染的方法。 聚合物可以是均聚物或共聚物。 在一个实施方案中，聚合物是包含酸官能化的含糖单体和丙烯酰胺的共聚物。
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公开(公告)号：US06187762B1
公开(公告)日：2001-02-13
申请号：US09286351
申请日：1999-04-05
IPC分类号： A61K3170
CPC分类号： C07H13/04 , C07D309/10 , C07H15/04 , C08F246/00
摘要： The present invention includes polymerizable monomers comprising a fucoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotavirus infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The glycoside moieties can be, for example, fucoside moieties or sialic acid moieties. The polymer can be a homopolyrner or a co-polymer. In one embodiment, the polymer is a copolymer comprising a glycoside-bearing monomer and a hydrophobic monomer. In another embodiment, the polymer to be administered comprises two or more different glycoside-bearing monomers.
摘要翻译： 本发明包括包含岩藻糖苷部分的可聚合单体。 在一个实施方案中，单体具有可聚合官能团，例如烯键，通过间隔基团例如亚烷基或其中一个或多个碳原子被 杂原子，例如氧，氮或硫原子。 本发明还包括包含一种或多种可以抑制或预防哺乳动物轮状病毒感染的岩藻糖苷部分的聚合物，例如侧壁ucoside部分。 这样的聚合物可以包括例如本发明的单体。 聚合物可以是均聚物或共聚物，并且可以具有例如聚丙烯酰胺，聚丙烯酸酯或聚苯乙烯主链。 在另一个实施方案中，本发明包括通过向哺乳动物施用治疗有效量的包含一个或多个糖苷部分的聚合物，例如侧链糖苷部分，来治疗哺乳动物例如人的轮状病毒感染的方法。 糖苷部分可以是例如岩藻糖苷部分或唾液酸部分。 聚合物可以是均聚物或共聚物。 在一个实施方案中，聚合物是包含含糖苷单体和疏水性单体的共聚物。 在另一个实施方案中，待施用的聚合物包含两种或更多种不同的含糖苷单体。
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公开(公告)号：US5939537A
公开(公告)日：1999-08-17
申请号：US881955
申请日：1997-06-25
IPC分类号： C07H15/04 , A61K31/785 , C08F12/14 , C08F16/26 , C08F20/26 , C08F20/28 , C08F20/38 , C08F20/58 , C08F26/02 , C08F220/56 , C07H15/00 , C07H17/00 , C07H17/02
CPC分类号： A61K31/785 , C08F20/28 , C08F20/38 , C08F20/58
摘要： The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising pendant acid-functionalized glycoside moieties. The present invention also provides a method for treating a microbial infection in a mammal by administering to the mammal a therapeutically effective amount of a polymer comprising one or more acid-functionalized glycoside moieties.
摘要翻译： 本发明包括包含酸官能化的糖苷部分的可聚合单体。 单体可以具有聚合性官能团，例如烯键，酸官能化糖苷部分通过间隔基团连接到其上，例如亚烷基或其中一个或多个碳原子被 杂原子，例如氧，氮或硫原子。 本发明还包括含有酸功能化的糖苷部分侧链的聚合物。 本发明还提供了通过向哺乳动物施用治疗有效量的包含一个或多个酸官能化糖苷部分的聚合物来治疗哺乳动物微生物感染的方法。
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