公开(公告)号：US20240384347A1

公开(公告)日：2024-11-21

申请号：US18694166

申请日：2022-09-23

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Miranda ORR

IPC: C12Q1/6883 ,  A61B6/03 ,  A61B6/50 ,  C07K16/40

Abstract: Provided herein according to some embodiments is a method of detecting senescent cells and/or neurofibrillary tangles in a subject, comprising: assaying for the expression of CDKN2D in the brain of the subject; and comparing the amount of CDKN2D expression to a control, whereby increased CDKN2D expression relative to the control is indicative of the presence of neurofibrillary tangles in the subject. Methods of treating and monitoring a subject so identified are also provided.