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公开(公告)号：US20250110120A1
公开(公告)日：2025-04-03
申请号：US18833026
申请日：2022-01-31
Applicant: GENESPECTOR S.R.O. , WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Stanislav KMOCH , Martina ZIVNA , Jan ZIVNY , Helena TRESLOVA , Anthony BLEYER , Kendrah KIDD
IPC: G01N33/543 , G01N33/68
Abstract: Method for determination of mutated form of mucin-1 protein in a biological sample comprising steps of adding biological sample to immobilized antibody against mutated form of VNTR MUC1fs, adding antibody against wild-type VNTR MUC1fs to portion of this mixture and performing quantitative analysis, wherein antibody against mutated form of VNTR MUC1fs is added to remainder of mixture of biological sample with immobilized antibody against mutated form of VNTR MUC1fs quantitative analysis is performed. Determination of concentration of MUC1fs in sample and determination of length of mutated or wild-type VNTR MUC1fs in sample is performed using appropriate calibration curves obtained by analyzing standard containing at least one epitope of mutated and at least one epitope of wild-type VNTR MUC1fs.
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公开(公告)号：US20250011316A1
公开(公告)日：2025-01-09
申请号：US18811956
申请日：2024-08-22
Applicant: Wake Forest University Health Sciences
Inventor： W. Todd Lowther , Terrence L. Smalley, JR. , Kimberly J. Nelson
IPC: C07D417/04 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K38/00 , A61K47/55 , C07D277/56 , C07D417/12 , C07D417/14 , C07K7/06
Abstract: Provided according to some embodiments is a compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. Pharmaceutical compositions comprising the same and methods of use for treating cancer and inhibiting PRX3 are also provided.
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公开(公告)号：US12083339B2
公开(公告)日：2024-09-10
申请号：US16340106
申请日：2017-10-06
Inventor： Jill W. Ivey , Eduardo L. Latouche , Scott S. Verbridge , Rafael V. Davalos , Glenn J. Lesser , Waldemar Debinski
CPC classification number: A61N1/327 , A61B18/12 , A61B18/1233 , A61K38/19 , A61N1/05 , A61N1/06 , A61B2017/00172 , A61B2018/00613 , A61B2018/00732 , A61B2018/00767 , A61B2018/126 , A61B2018/128 , A61K38/1793
Abstract: Described herein are methods of electroporation that can include the steps of contacting a cell that is responsive to an EphA2 receptor ligand with an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to the cell. Also described herein are methods of treating cancer in a subject in need thereof, wherein the methods can include the steps of administering an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to a location on or within the subject.
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公开(公告)号：US12038432B2
公开(公告)日：2024-07-16
申请号：US16966406
申请日：2019-02-01
Applicant: Wake Forest University Health Sciences
Inventor： Aleksander Skardal , Konstantinos Votanopoulos
CPC classification number: G01N33/5082 , A61K35/17 , A61P35/00 , C12N5/0634 , C12N5/0693 , C12N5/0697 , G01N33/5011
Abstract: Described herein are organoids that include at least one type of immune cell along with systems and devices including the same. Methods of preparing and using such organoids, devices and systems are also described herein.
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5.发明授权公开(公告)号：US11931526B2
公开(公告)日：2024-03-19
申请号：US18296906
申请日：2023-04-06
Applicant: Wake Forest University Health Sciences
Inventor： James D. Turner , Sean Dobson
CPC classification number: A61M25/0113 , A61B8/0841 , A61B34/20 , A61B2034/2063
Abstract: A medical device is provided that can be held and operated with a single hand to cause a catheter to be placed at a selected location in a patient's body. The user's other hand is free to perform other tasks, such as operating an ultrasound probe, for example. The medical device may also include a valve that can be operated with the same hand that holds the medical device to open a port to cause a fluid, such as a nerve block agent, for example, to be injected into the patient's body at the selected location.
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Patent Agency Ranking
公开(公告)号：US11931428B2
公开(公告)日：2024-03-19
申请号：US16947869
申请日：2020-08-21
Applicant: Wake Forest University Health Sciences
Inventor： John C. Lukesh, III
CPC classification number: A61K49/0039 , A61K9/0019 , A61K9/0053 , C07F11/00
Abstract: Provided herein is a compound of formula I:
and the use thereof for detecting the presence of hydrogen sulfide in cells or tissues in vitro or in vivo. The detecting may be useful, for example, in diagnosing cancer or other diseases related to imbalanced hydrogen sulfide (H2S) production such as neurodegenerative diseases.-
公开(公告)号：US20240075256A1
公开(公告)日：2024-03-07
申请号：US18262226
申请日：2022-01-26
Applicant: Wake Forest University Health Sciences , Emory University , Children’s Healthcare of Atlanta, Inc.
Inventor： Lucas Paul Neff , Matthew S. Clifton
IPC: A61M25/10 , A61B17/221 , A61M29/02
CPC classification number: A61M25/1011 , A61B17/221 , A61M29/02 , A61B2017/22038
Abstract: Multi-lumen catheters with first and second expandable members are configured so that one expandable member dilates the Sphincter of Oddi and the second anchors within the biliary duct distal to the Common Bile Duct/Cystic Duct junction or within the cystic duct. The multi-lumen catheters include a primary lumen sized and configured for delivering a flushing agent to remove gallstones together or separately with a dye to complete a Cholangiogram and also include at least one lumen in fluid communication with the first and second expandable members.
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公开(公告)号：US20230405116A1
公开(公告)日：2023-12-21
申请号：US18037708
申请日：2021-11-19
Applicant: Wake Forest University Health Sciences
Inventor： Baisong LU , Anthony ATALA
CPC classification number: A61K39/4611 , C12N15/11 , C12N9/22 , C12N9/78 , C12Y305/04004 , C12N15/86 , A61K48/0041 , C12N2310/20 , C12N2310/16 , C12N2310/531
Abstract: Provided herein are compositions and methods for editing the genome of a eukaryotic cell.
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公开(公告)号：US20230278957A1
公开(公告)日：2023-09-07
申请号：US18040192
申请日：2021-08-03
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Fred W. PERRINO , Thomas HOLLIS , Scott E. HARVEY , Wayne O. HEMPHILL
IPC: C07D209/48 , C07C309/44 , C07D417/12 , C07D405/14 , C07D413/14 , C07D405/12 , C07D513/14 , C07D471/14
CPC classification number: C07D209/48 , C07C309/44 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D471/14 , C07D513/14
Abstract: Active compounds of Formulas I - IX are provided herein that are useful as TREX1 inhibitors, which in turn is useful for stimulating the cGAS-STING pathway. As such, these compounds may be used in a method of treating disease or disorder in which modulation of TREX1 would be of benefit, such as a cancer, viral infection, or autoimmune disease.
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公开(公告)号：US11708411B2
公开(公告)日：2023-07-25
申请号：US15106071
申请日：2014-12-22
Applicant: Wake Forest University Health Sciences
Inventor： Karen Haas , Jerome Mckay
IPC: A61K39/00 , A61K39/116 , A61K39/09 , A61K39/395 , C07K16/28
CPC classification number: C07K16/2827 , A61K39/092 , A61K39/116 , A61K39/3955 , A61K2039/505 , A61K2039/6087 , A61K2039/70 , C07K2317/76
Abstract: The presently disclosed subject matter provides therapeutic methods and compositions for the treatment of bacterial infections caused by Streptococcus pneumoniae. In particular, methods are provided for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines in a subject in need thereof comprising administering to the subject an effective amount of an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide. Immunogenic compositions are also provided comprising one or more pneumococcal polysaccharide antigens and an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide.
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