公开(公告)号：US20190375860A1

公开(公告)日：2019-12-12

申请号：US16311992

申请日：2017-06-30

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES ,  WAKE FOREST UNIVERSITY

Inventor： Mark E. WELKER ,  Emmanuel C. OPARA ,  Surya R. BANKS ,  Amber N. WEISSENENFLUH

IPC: C08B37/00 ,  A61K47/69

Abstract: Modified alginates are described herein along with hydrogels comprising the same. A modified alginate may be prepared by reacting alginate and an aromatic compound (e.g., an aromatic amine) and/or pH sensitive compound. The modified alginates, hydrogels, and/or methods described herein may be used to coat and/or encapsulate at least a portion of a bioactive substance, optionally for oral delivery in humans and other animals.