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11 条记录 (耗时 0.018 秒)

    3-substituted chromones
    4.
    发明授权
    3-substituted chromones 失效
    3-取代的CHROMONES

    公开(公告)号：US3767679A

    公开(公告)日：1973-10-23

    申请号：US3767679D

    申请日：1971-09-13

    申请人： WARNER LAMBERT CO

    发明人： VON STRANDTMANN M ,  KLUTCHKO S ,  SHAVEL J

    IPC分类号： C07D311/22 ,  C07D7/34

    CPC分类号： C07D311/22

    摘要： 3-SUBSTITUTED CHROMONES HAVING THE FOLLOWING STRUCTURAL FORMULAS ARE DISCLOSED.

    3-(R1-CH2-),4-(O=),R2-4H-CHROMENE, OR ((4-(O=),R2-4H-

    CHROMEN-3-YL)-CH2)2-R3

    WHEREIN R1 IS HALOGEN, CYANO, CARBOXY, CARBOXAMIDE, AMINO, ALKYLAMINO, ARYLAMINO, ALKOXY, N-ALKYLHYDROXYLAMINO, ACYLOXY, AMIDO AND IMIDO; R2 IS HYDROGEN, HALOGEN, LOWER ALKOXY; AND R3 IS AMINO, ALKYLENDIAMINO SUCH AS ETHYLENEDIAMINO, ETC., CYCLIC DIAMINO SUCH AS PIPERAZINE-1,4-DIYL-HYDROXYLAMINO, -O- OR -S-. THEY ARE USEFUL IN PREVENTING ALLERGIC MANIFESTATIONS. COMPOUNDS OF THIS TYPE ARE PREPARED FROM 3-(HYDROXYMETHYL)CHROMONES.

    Substituted pyrano(3,2-c)(1,2)benzothiazine 6,6-dioxides
    5.
    发明授权
    Substituted pyrano(3,2-c)(1,2)benzothiazine 6,6-dioxides 失效
    取代的吡咯烷（3,2-C）（1,2）苯并噻嗪6,6-二氧化物

    公开(公告)号：US3855216A

    公开(公告)日：1974-12-17

    申请号：US36539973

    申请日：1973-05-29

    申请人： WARNER LAMBERT CO

    发明人： KAMINSKY D ,  KLUTCHKO S ,  VON STRANDTMANN M

    IPC分类号： C07D279/02 ,  C07D513/04 ,  C07F5/02 ,  C07D99/10

    CPC分类号： C07D513/04 ,  C07D279/02 ,  C07F5/022

    摘要： Novel pyrano(3,2-c)(1,2)benzothiazine 6,6-dioxides are disclosed, substituted on the 3 position by a lower alkyl, carboxaldehyde, or hydroxymethyl group and, optionally substituted on the 5 position by a lower alkyl group. The corresponding aldehyde thiosemicarbazone derivatives of these compounds are also disclosed. Pharmaceutical compositions containing the substituted pyrano(3,2-c)(1,2)benzothiazine 6,6dioxides of this invention are useful in the treatment of hyperacidity; certain of these compounds also demonstrate antiallergy activity.

    摘要翻译： 公开了新的吡喃并[3,2-c] [1,2]苯并噻嗪6,6-二氧化物，在3位被低级烷基，甲醛或羟甲基取代，并且任选地在5位被低级烷基 组。 还公开了这些化合物的相应的醛缩氨基硫脲类衍生物。 含有本发明取代的吡喃并[3,2-c] [1,2]苯并噻嗪6,6-二氧化物的药物组合物可用于治疗胃酸过多; 这些化合物中的某些也表现出抗过敏​​活性。

    3-substituted pyrimido(4,5-b)indoles
    8.
    发明授权
    3-substituted pyrimido(4,5-b)indoles 失效
    3-取代的吡咯（4,5-B）吲哚

    公开(公告)号：US3847920A

    公开(公告)日：1974-11-12

    申请号：US36136573

    申请日：1973-05-17

    申请人： WARNER LAMBERT CO

    发明人： KLUTCHKO S ,  VON STRANDTMANN M

    IPC分类号： C07D209/40 ,  C07D487/04 ,  C07D51/42

    CPC分类号： C07D487/04 ,  C07D209/40 ,  Y10S514/927

    摘要： 1. A MEMBER SELECTED FROM THE GROUP CONSISTING OF COMPOUNDS OF THE FORMULAS:

    3-R-PYRIMIDO(4,5-B)INDOLIUM X(-) OR 3-R-3,4-DIHYDRO-

    PYRIMIDO(4,5-B)INDOLE

    WHEREIN R IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKYL, DIALKYLAMINOALKYL, MONOHYDROXYALKYL IN WHICH ALKYL HAS 1 TO 7 CARBON ATOMS, PHENYL, ALKYLPHENYL HAVING A TOTAL OF 7 TO 10 CARBON ATOMS, N-OXIDE, CARBOXYMETHYL, CARBOXYMETHYL ANION, AND X IS CHLORO OR BROMO OR NONEXISTENT IN THE CASE OF ZWITTERIONS.

    3-(hydroxymethyl)chromones
    10.
    发明授权
    3-(hydroxymethyl)chromones 失效
    3-（羟甲基）CHROMONES

    公开(公告)号：US3798240A

    公开(公告)日：1974-03-19

    申请号：US3798240D

    申请日：1972-11-24

    申请人： WARNER LAMBERT CO

    发明人： VON STRANDTMANN M ,  SHAVEL J ,  KLUTCHKO S ,  COHEN M

    IPC分类号： C07D311/22 ,  C07D311/92 ,  C07D7/34

    CPC分类号： C07D311/92 ,  C07D311/22

    摘要： THE PRESENT INVENTION RELATES TO COMPOUNDS OF TYPE I:

    3-(HO-CH2-),4-(O=),R1,R2-CHROMAN

    WHEREIN R1 AND R2 ARE HYDROGEN, HALOGEN, ALKYL, ARALKYL, ARYL, ALKOXY, ACYLAMINO, HYDROXY, OR TAKEN TOGETHER R1 AND R2 FROM AN AROMATIC RING. THESE COMPOUNDS ARE PREPARED FROM THE CORRESPONDING O-HYDROXY-$(METHYLSULFINYL)ACETOPHENONES. THESE COMPOUNDS ARE USEFUL IN ALLEVIATING ALLERGIC MANIFESTATIONS.