公开(公告)号：US20250135036A1

公开(公告)日：2025-05-01

申请号：US18695348

申请日：2022-09-26

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Christopher Michael Acker ,  Onanong Chivatakarn ,  Prashant Monian ,  Chikdu Shakti Shivalila ,  Subramanian Marappan ,  Chandra Vargeese ,  Pachamuthu Kandasamy ,  Genliang Lu ,  Hui Yu ,  David Charles Donnell Butler ,  Luciano Henrique Apponi ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  David John Boulay ,  Andrew Guzior Hoss ,  Jigar Desai ,  Jack David Godfrey ,  Hailin Yang ,  Naoki Iwamoto ,  Jayakanthan Kumarasamy ,  Anthony Lamattina ,  Ian Chandler Harding ,  Jesse Turner

IPC: A61K48/00 ,  C12N9/78 ,  C12N15/113 ,  C12N15/87

Abstract: Among other things, the present disclosure provides oligonucleotides, compositions and methods thereof that can bring about specific editing of a target adenosine in a target RNA molecule. Such oligonucleotides, compositions and methods are useful to treat, prevent, or ameliorate MECP2 associated disorders, diseases and syndromes that can benefit from adenosine modification.

公开(公告)号：US20240384273A1

公开(公告)日：2024-11-21

申请号：US18667824

申请日：2024-05-17

Applicant: Wave Life Sciences Ltd.

Inventor： Chandra Vargeese ,  Naoki Iwamoto ,  Wei Liu ,  Mugdha Bedekar ,  Brett Schrand ,  Priyank Shiva Prakasha ,  Anthony Lamattina ,  Luciano H. Apponi

IPC: C12N15/113

Abstract: The present disclosure provides HSD17B13-related double stranded oligonucleotides, compositions, and methods of using such double stranded oligonucleotides and compositions for preventing and/or treating various conditions, disorders, or diseases associated with expression of HSD17B13. In some embodiments, the provided double stranded oligonucleotides and compositions comprise nucleobase modifications, sugar modifications, internucleotidic linkage modifications and/or patterns thereof, and have improved properties, activities and/or selectivities. In some embodiments, the provided double stranded oligonucleotides and compositions target HSD17B13.

公开(公告)号：US20240026358A1

公开(公告)日：2024-01-25

申请号：US18252029

申请日：2022-03-11

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Prashant Monian ,  Chikdu Shakti Shivalila ,  Subramanian Marappan ,  Chandra Vargeese ,  Pachamuthu Kandasamy ,  Genliang Lu ,  Hui Yu ,  David Charles Donnell Butler ,  Luciano Henrique Apponi ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  David John Boulay ,  Andrew Guzior Hoss ,  Jigar Desai ,  Jack David Godfrey ,  Hailin Yang ,  Naoki Iwamoto ,  Jayakanthan Kumarasamy ,  Anthony Lamattina ,  Tom Liantang Pu

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/322 ,  C12N2310/321 ,  C12N2310/315 ,  C12N2320/34

Abstract: Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

公开(公告)号：US20230392137A1

公开(公告)日：2023-12-07

申请号：US17953292

申请日：2022-09-26

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Prashant Monian ,  Chikdu Shakti Shivalila ,  Subramanian Marappan ,  Chandra Vargeese ,  Pachamuthu Kandasamy ,  Genliang Lu ,  Hui Yu ,  David Charles Donnell Butler ,  Luciano Henrique Apponi ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  David John Boulay ,  Andrew Guzior Hoss ,  Jigar Desai ,  Jack David Godfrey ,  Hailin Yang ,  Naoki Iwamoto ,  Jayakanthan Kumarasamy ,  Anthony Lamattina ,  Tom Liantang Pu

IPC: C12N15/10 ,  C12N15/113

CPC classification number: C12N15/102 ,  C12N15/1135

Abstract: Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.