公开(公告)号：US20110097263A1

公开(公告)日：2011-04-28

申请号：US12606529

申请日：2009-10-27

申请人： WEI-CHUAN HSU ,  TE-WEI LEE ,  CHIA-YU YU ,  CHIH-HSIEN CHANG ,  TSUI-JUNG CHANG

发明人： WEI-CHUAN HSU ,  TE-WEI LEE ,  CHIA-YU YU ,  CHIH-HSIEN CHANG ,  TSUI-JUNG CHANG

IPC分类号： A61K51/04 ,  A61K51/00

CPC分类号： A61K51/1234 ,  A61K47/6913

摘要： A kit formulation for the preparation of immunoliposome drug in combined chemotherapy and radionuclide therapy is disclosed, which consists: (1) a vial A containing proteins; (2) a vial B containing Traut's reagent; (3) a vial C containing DSPC, Cholesterol, mPEG-DSPE, Mal-DSPE-PEG and chemotherapy drug; (4) a vial D containing BMEDA, gluconate acetate, SnCl2; (5) a vial E which containing radionuclide solution. The procedure using the kit comprises: (i) withdraw the radionuclide solution from the vial E; (ii) inject the solution into the vial D for enabling reaction; (iii) withdraw the contents of the vial B and inject into the vial A; (iv) withdraw the contents of the protein and Traut's reagent mixtures from the vial A and inject into the vial C for enabling reaction; (v) withdraw the contents of the immunoliposome from the vial C; (vi) inject the immunoliposome into the vial D of step (ii) for enabling reaction.

摘要翻译： 公开了用于在联合化疗和放射性核素治疗中制备免疫脂质体药物的试剂盒制剂，其包括：（1）含有蛋白质的小瓶A; （2）含有Traut试剂的小瓶B; （3）含有DSPC，胆固醇，mPEG-DSPE，Mal-DSPE-PEG和化疗药物的小瓶C; （4）含有BMEDA，葡萄糖酸乙酯，SnCl 2的小瓶D; （5）含有放射性核素溶液的小瓶E. 使用试剂盒的方法包括：（i）从小瓶E中取出放射性核素溶液; （ii）将溶液注入小瓶D以进行反应; （iii）取出小瓶B的内容物并注入小瓶A; （iv）从小瓶A取出蛋白质和Traut试剂混合物的内容物，并注入小瓶C以进行反应; （v）从小瓶C取出免疫脂质体的内容物; （vi）将免疫脂质体注射到步骤（ii）的小瓶D中以进行反应。

公开(公告)号：US20120107232A1

公开(公告)日：2012-05-03

申请号：US13169268

申请日：2011-06-27

申请人： WEI-CHUAN HSU ,  Te-Wei Lee ,  Shu-Pei Chiu ,  Yi-Ting Tsai ,  Gann Ting

发明人： WEI-CHUAN HSU ,  Te-Wei Lee ,  Shu-Pei Chiu ,  Yi-Ting Tsai ,  Gann Ting

IPC分类号： A61K51/12 ,  A61P35/00

CPC分类号： A61K51/1234

摘要： A kit for preparing a radiolabeled liposome is provided, the kit including a liposome suspension and a radionuclide, wherein the liposome suspension includes a conjugate with a structure of [chelator-hydrophilic polymer-lipid]. A method for preparing a radiolabeled liposome using the kit is also disclosed herein, thereby the radiolabeled liposome being produced with the conjugate connected to the surface therein. The advantages of the present disclose such as simple, convenient and without purifying for the produced radiolabeled liposome are thus achieved. Further, the produced radiolabeled liposome has a high specific activity and a high sensitivity and suits for the clinical use.

摘要翻译： 提供了用于制备放射性标记的脂质体的试剂盒，该试剂盒包括脂质体悬浮液和放射性核素，其中脂质体悬浮液包括具有[螯合剂 - 亲水性聚合物 - 脂质]结构的缀合物。 本文还公开了使用试剂盒制备放射性标记的脂质体的方法，由此产生放射性标记的脂质体，其中缀合物连接到其表面。 因此实现了本发明公开的优点，例如简单，方便和不需要纯化用于所制备的放射性标记的脂质体。 此外，所制备的放射性标记的脂质体具有高比活度和高灵敏度，适用于临床应用。