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公开(公告)号:US20100173362A1
公开(公告)日:2010-07-08
申请号:US12632765
申请日:2009-12-07
申请人: WILLIAM M. WINSTON, JR. , S. KIRK WRIGHT , MAY HAN , LYNE BREAULT , JIE LIN , BIJAN ETEMAD-GILBERTSON , CHRISTINE KNUEHL , JENO GYURIS , ARNOLD HORWITZ
发明人: WILLIAM M. WINSTON, JR. , S. KIRK WRIGHT , MAY HAN , LYNE BREAULT , JIE LIN , BIJAN ETEMAD-GILBERTSON , CHRISTINE KNUEHL , JENO GYURIS , ARNOLD HORWITZ
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译: 本发明提供结合并中和肝细胞生长因子(HGF),特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性,结合蛋白可用于治疗某些HGF应答性病症,例如某些HGF反应性肿瘤。