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公开(公告)号：US20110256154A1
公开(公告)日：2011-10-20
申请号：US13082852
申请日：2011-04-08
申请人： Sylvie Vincent , William M. Winston, JR. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Botega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
发明人： Sylvie Vincent , William M. Winston, JR. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Botega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： A61K39/395 , C07H21/00 , C12P21/00 , C12N15/63 , C12N1/00 , C12N5/10 , C07K16/28 , A61P35/00
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
摘要翻译： 公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。 抗体可用于治疗与ErbB3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。
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公开(公告)号：US20110236377A1
公开(公告)日：2011-09-29
申请号：US13051474
申请日：2011-03-18
申请人： May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
IPC分类号： A61K39/395 , C12N5/02 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20110229462A1
公开(公告)日：2011-09-22
申请号：US13051481
申请日：2011-03-18
申请人： William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
IPC分类号： A61K39/395 , A61P35/00 , C12N5/09
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US20080038257A1
公开(公告)日：2008-02-14
申请号：US11757094
申请日：2007-06-01
申请人： May Han , S. Wright , William Winston , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Wright , William Winston , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US08575318B2
公开(公告)日：2013-11-05
申请号：US13589652
申请日：2012-08-20
申请人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20100173362A1
公开(公告)日：2010-07-08
申请号：US12632765
申请日：2009-12-07
申请人： WILLIAM M. WINSTON, JR. , S. KIRK WRIGHT , MAY HAN , LYNE BREAULT , JIE LIN , BIJAN ETEMAD-GILBERTSON , CHRISTINE KNUEHL , JENO GYURIS , ARNOLD HORWITZ
发明人： WILLIAM M. WINSTON, JR. , S. KIRK WRIGHT , MAY HAN , LYNE BREAULT , JIE LIN , BIJAN ETEMAD-GILBERTSON , CHRISTINE KNUEHL , JENO GYURIS , ARNOLD HORWITZ
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20080108565A1
公开(公告)日：2008-05-08
申请号：US11757059
申请日：2007-06-01
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US08580930B2
公开(公告)日：2013-11-12
申请号：US13589664
申请日：2012-08-20
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US08187601B2
公开(公告)日：2012-05-29
申请号：US12494965
申请日：2009-06-30
申请人： Zhigang Weng , William M. Winston, Jr. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
发明人： Zhigang Weng , William M. Winston, Jr. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.
摘要翻译： 公开了结合并抑制成纤维细胞生长因子受体3（FGFR3）活化的单克隆抗体。 抗体可用于治疗与FGFR3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。
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公开(公告)号：US07943344B2
公开(公告)日：2011-05-17
申请号：US12632765
申请日：2009-12-07
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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