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公开(公告)号：US09556217B2
公开(公告)日：2017-01-31
申请号：US14931225
申请日：2015-11-03
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION , The Board of Trustees of the Leland Stanford Junior University
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Brian Kobilka , Soren Rasmussen
CPC classification number: C07J17/005 , A61K9/1075 , C07J41/0061 , C07J71/0005
Abstract: Bringing membrane proteins into aqueous solution generally requires the use of detergents or other amphiphilic agents. The invention provides a new class of amphiphiles, each of which includes a multi-fused ring system as a lipophilic group. These new amphiphiles confer enhanced stability to a range of membrane proteins in solution relative to conventional detergents, leading to improved structural and functional stability of membrane proteins, including integral membrane proteins. Accordingly, the invention provides new amphiphiles for biochemical manipulations and characterization of membrane proteins. These amphiphiles display favorable behavior with membrane proteins and can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.
Abstract translation: 将膜蛋白引入水溶液中通常需要使用洗涤剂或其他两亲剂。 本发明提供了一类新的两亲物，其中每一种都包括作为亲脂基团的多稠环体系。 这些新的两亲物相对于常规洗涤剂使溶液中的一系列膜蛋白质的稳定性提高，导致膜蛋白（包括整合的膜蛋白）的结构和功能稳定性得到改善。 因此，本发明提供用于生物化学操作和膜蛋白表征的新型两亲物。 这些两亲物显示出有利于膜蛋白的行为，并可用于帮助膜蛋白的溶解，分离，纯化，稳定，结晶和/或结构测定。
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公开(公告)号：US09206221B2
公开(公告)日：2015-12-08
申请号：US13826466
申请日：2013-03-14
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION , The Board of Trustees of the Leland Stanford Junior University
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Brian Kobilka , Soren Rasmussen
CPC classification number: C07J17/005 , A61K9/1075 , C07J41/0061 , C07J71/0005
Abstract: Bringing membrane proteins into aqueous solution generally requires the use of detergents or other amphiphilic agents. The invention provides a new class of amphiphiles, each of which includes a multi-fused ring system as a lipophilic group. These new amphiphiles confer enhanced stability to a range of membrane proteins in solution relative to conventional detergents, leading to improved structural and functional stability of membrane proteins, including integral membrane proteins. Accordingly, the invention provides new amphiphiles for biochemical manipulations and characterization of membrane proteins. These amphiphiles display favorable behavior with membrane proteins and can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.
Abstract translation: 将膜蛋白引入水溶液中通常需要使用洗涤剂或其他两亲剂。 本发明提供了一类新的两亲物，其中每一种都包括作为亲脂基团的多稠环体系。 这些新的两亲物相对于常规洗涤剂使溶液中的一系列膜蛋白质的稳定性提高，导致膜蛋白（包括整合的膜蛋白）的结构和功能稳定性得到改善。 因此，本发明提供用于生物化学操作和膜蛋白表征的新型两亲物。 这些两亲物显示出有利于膜蛋白的行为，并可用于帮助膜蛋白的溶解，分离，纯化，稳定，结晶和/或结构测定。
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公开(公告)号：US20130266656A1
公开(公告)日：2013-10-10
申请号：US13826466
申请日：2013-03-14
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Brian Kobilka , Soren Rasmussen
CPC classification number: C07J17/005 , A61K9/1075 , C07J41/0061 , C07J71/0005
Abstract: Bringing membrane proteins into aqueous solution generally requires the use of detergents or other amphiphilic agents. The invention provides a new class of amphiphiles, each of which includes a multi-fused ring system as a lipophilic group. These new amphiphiles confer enhanced stability to a range of membrane proteins in solution relative to conventional detergents, leading to improved structural and functional stability of membrane proteins, including integral membrane proteins. Accordingly, the invention provides new amphiphiles for biochemical manipulations and characterization of membrane proteins. These amphiphiles display favorable behavior with membrane proteins and can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.
Abstract translation: 将膜蛋白引入水溶液中通常需要使用洗涤剂或其他两亲剂。 本发明提供了一类新的两亲物，其中每一种都包括作为亲脂基团的多稠环体系。 这些新的两亲物相对于常规洗涤剂使溶液中的一系列膜蛋白质的稳定性提高，导致膜蛋白（包括整合的膜蛋白）的结构和功能稳定性得到改善。 因此，本发明提供用于生物化学操作和膜蛋白表征的新型两亲物。 这些两亲物显示出有利于膜蛋白的行为，并可用于帮助膜蛋白的溶解，分离，纯化，稳定，结晶和/或结构测定。
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