公开(公告)号：US20170342047A1

公开(公告)日：2017-11-30

申请号：US15482302

申请日：2017-04-07

Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

Inventor： Cheng-Chen Huang ,  Aaron P. Monte

IPC: C07D333/56 ,  C07D241/18 ,  C07D231/56 ,  C07D231/12 ,  C07D209/12 ,  C07C323/20 ,  C07C323/18 ,  C07D333/16 ,  C07C43/23

CPC classification number: C07D333/56 ,  C07C43/23 ,  C07C323/18 ,  C07C323/20 ,  C07D209/12 ,  C07D231/12 ,  C07D231/56 ,  C07D241/18 ,  C07D333/16

Abstract: The present invention provides a compound of Formula I, II or III or a salt or prodrug or derivative thereof that is useful for skin-whitening by inhibiting melanin formation and removing existing melanin and the inhibition of melanoma growth and/or the removal of existing melanoma cells.

公开(公告)号：US10112881B2

公开(公告)日：2018-10-30

申请号：US15327721

申请日：2015-07-21

Applicant: WiSys Technology Foundation, Inc.

Inventor： Cheng-Chen Huang ,  Aaron P. Monte

IPC: C07C43/23 ,  A61Q19/02 ,  A61K8/34

Abstract: The present invention provides a compound of Formula I, wherein R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is CnH(2n+1)O, wherein n is 1-10, R2 is OH or CnH(2n+1)O, wherein n is 1-10, A, B and R1, R2, R5, R6, and R7 are separately and independently selected from a group consisting of H, alkyl, hydroxyl, halo, nitro and aryl groups, R11 is an alkyl or an aryl group and L is an optional linker or linking group, with x=0 or 1, i.e., if x=0, no linking group is present, or a salt or prodrug or derivative thereof that is a skin-lightening agent useful for the inhibition of melanin synthesis and/or the removal of existing melanin to function as a skin-lightening agent.

公开(公告)号：US20170197897A1

公开(公告)日：2017-07-13

申请号：US15327721

申请日：2015-07-21

Applicant: Wisys Technology Foundation Inc.

Inventor： Cheng-Chen Huang ,  Aaron P. Monte

IPC: C07C43/23 ,  A61Q19/02 ,  A61K8/34

CPC classification number: C07C43/23 ,  A61K8/33 ,  A61K8/347 ,  A61K31/085 ,  A61Q19/02 ,  C07C43/215

Abstract: The present invention provides a compound of Formula I, II or III or a salt or prodrug derivative thereof that is a skin-lightening agent useful for the inhibition of melanin synthesis and/or the removal of existing melanin to function as a skin-lightening agent.

公开(公告)号：US10550095B2

公开(公告)日：2020-02-04

申请号：US15482302

申请日：2017-04-07

Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

Inventor： Cheng-Chen Huang ,  Aaron P. Monte

IPC: C07D333/56 ,  C07C43/23 ,  C07C323/18 ,  C07D333/16 ,  C07D231/12 ,  C07D209/12 ,  C07D231/56 ,  C07D241/18 ,  C07C323/20

Abstract: The present invention provides a compound of Formula I, II or III or a salt or prodrug or derivative thereof that is useful for skin-whitening by inhibiting melanin formation and removing existing melanin and the inhibition of melanoma growth and/or the removal of existing melanoma cells.