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1.发明公开公开(公告)号：US20230287378A1
公开(公告)日：2023-09-14
申请号：US17996441
申请日：2021-04-21
发明人： Liqin XU , Fenglin WANG , Yangfang ZHOU , Yangzi PENG , Jiexing CAI , Weichang ZHOU , Xiaobo XI , Weiwen WANG , Tingting WANG , Chunsheng YANG , Quanmin CHEN , Jeremy GUO
CPC分类号： C12N9/2402 , A61K38/47 , C12N9/1051 , C12N15/907 , C12Y204/01101 , C12Y302/01045 , C12N2310/20
摘要： Provided are a genetically modified cell line producing a recombinant glycoprotein having a mannose-terminated N-glycan and a method for producing the recombinant glycoprotein or a method for generating the cell, clone or cell line. The cell line comprises an insertion of less than 600 bp in the coding region of a chromosomal sequence encoding MGAT1.
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2.发明公开公开(公告)号：US20240167010A9
公开(公告)日：2024-05-23
申请号：US17996441
申请日：2021-04-21
发明人： Liqin XU , Fenglin WANG , Yangfang ZHOU , Yangzi PENG , Jiexing CAI , Weichang ZHOU , Xiaobo XI , Weiwen WANG , Tingting WANG , Chunsheng YANG , Quanmin CHEN , Jeremy GUO
CPC分类号： C12N9/2402 , A61K38/47 , C12N9/1051 , C12N15/907 , C12Y204/01101 , C12Y302/01045 , C12N2310/20
摘要： Provided are a genetically modified cell line producing a recombinant glycoprotein having a mannose-terminated N-glycan and a method for producing the recombinant glycoprotein or a method for generating the cell, clone or cell line. The cell line comprises an insertion of less than 600 bp in the coding region of a chromosomal sequence encoding MGAT1.
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