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公开(公告)号：US08465970B2
公开(公告)日：2013-06-18
申请号：US11246902
申请日：2005-10-07
申请人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner , Dmitri Menn
发明人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner , Dmitri Menn
IPC分类号： C12M1/12
CPC分类号： A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
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公开(公告)号：US20060154357A1
公开(公告)日：2006-07-13
申请号：US11246013
申请日：2005-10-07
申请人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner , Dmitri Menn
发明人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner , Dmitri Menn
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0247
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
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公开(公告)号：US20060154358A1
公开(公告)日：2006-07-13
申请号：US11246902
申请日：2005-10-07
申请人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner , Dmitri Menn
发明人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner , Dmitri Menn
IPC分类号： A01N1/02
CPC分类号： A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
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公开(公告)号：US09301519B2
公开(公告)日：2016-04-05
申请号：US11246013
申请日：2005-10-07
申请人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner
发明人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Ahmed Elbetanony , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Scott Newell , Burt Ochs , Dennis Sousa , Ronald Taylor , Jonathan Rourke , Hossam Algamil , David Carpenter , Robert Havner , Dmitri Menn
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0247
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
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公开(公告)号：US07651835B2
公开(公告)日：2010-01-26
申请号：US11246905
申请日：2005-10-07
申请人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Burt Ochs , Scott Newell , Ronald Taylor , Hossam Algamil , Thomas Bishop , Robert Havner , Dmitri Menn
发明人： Waleed Hassanein , Richard Bringham , Giovanni Cecere , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Burt Ochs , Scott Newell , Ronald Taylor , Hossam Algamil , Thomas Bishop , Robert Havner , Dmitri Menn
IPC分类号： A01N1/02
CPC分类号： A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
摘要翻译： 在各种实施例中，本发明提供了与离体器官护理相关的系统，装置和方法。 在某些实施方案中，本发明涉及在近生理条件下离体维持器官。
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公开(公告)号：US20070190636A1
公开(公告)日：2007-08-16
申请号：US11246905
申请日：2005-10-07
申请人： Waleed Hassanein , Thomas Bishop , Richard Bringham , Giovanni Cecere , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Burt Ochs , Scott Newell , Ronald Taylor , Hassam Algamil , Robert Havner , Dmitri Menn
发明人： Waleed Hassanein , Thomas Bishop , Richard Bringham , Giovanni Cecere , Robert Fishman , Larry Goff , Tamer Khayal , Stanley Kyi , Burt Ochs , Scott Newell , Ronald Taylor , Hassam Algamil , Robert Havner , Dmitri Menn
CPC分类号： A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
摘要翻译： 在各种实施例中，本发明提供了与离体器官护理相关的系统，装置和方法。 在某些实施方案中，本发明涉及在近生理条件下离体维持器官。
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公开(公告)号：US20060154359A1
公开(公告)日：2006-07-13
申请号：US11246903
申请日：2005-10-07
申请人： Waleed Hassanein , Robert Fishman , Stanley Kyi , Scott Newell , Burt Ochs , Jonathan Rourke , Robert Havner
发明人： Waleed Hassanein , Robert Fishman , Stanley Kyi , Scott Newell , Burt Ochs , Jonathan Rourke , Robert Havner
IPC分类号： A01N1/02
CPC分类号： A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
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公开(公告)号：US09055740B2
公开(公告)日：2015-06-16
申请号：US11246903
申请日：2005-10-07
申请人： Waleed Hassanein , Robert Fishman , Stanley Kyi , Scott Newell , Burt Ochs , Jonathan Rourke , Robert Havner
发明人： Waleed Hassanein , Robert Fishman , Stanley Kyi , Scott Newell , Burt Ochs , Jonathan Rourke , Robert Havner
CPC分类号： A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
摘要： The invention provides, in various embodiments, systems and devices relating to a blood product heater for use in an ex-vivo organ care. In certain embodiments, the invention relates to maintaining a perfusion fluid flowing through the heater at near-physiologic conditions.
摘要翻译： 本发明在各种实施例中提供了与用于体外器官护理的血液制品加热器有关的系统和装置。 在某些实施方案中，本发明涉及在近生理条件下保持流过加热器的灌注流体。
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公开(公告)号：US20090197240A1
公开(公告)日：2009-08-06
申请号：US12099715
申请日：2008-04-08
申请人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
发明人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
摘要翻译： 维持，评估和提供肺外治疗的方法和系统。 所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。 长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。 评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。
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公开(公告)号：US08420380B2
公开(公告)日：2013-04-16
申请号：US12099717
申请日：2008-04-08
申请人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
发明人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
IPC分类号： A01N1/02
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
摘要翻译： 维持，评估和提供肺外治疗的方法和系统。 所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。 长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。 评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。
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