公开(公告)号：US08420380B2

公开(公告)日：2013-04-16

申请号：US12099717

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract translation: 维持，评估和提供肺外治疗的方法和系统。 所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。 长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。 评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。

公开(公告)号：US20090197292A1

公开(公告)日：2009-08-06

申请号：US12099687

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: C12Q1/02 ,  C12M1/00

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US10750738B2

公开(公告)日：2020-08-25

申请号：US12099687

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Thomas H. Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Thomas H. Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: C12Q1/02 ,  C12M1/00 ,  A01N1/02

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US09462802B2

公开(公告)日：2016-10-11

申请号：US12099725

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US09247728B2

公开(公告)日：2016-02-02

申请号：US12099715

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: A61M16/00 ,  A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US20090197325A1

公开(公告)日：2009-08-06

申请号：US12099728

申请日：2008-04-08

Applicant: Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

Inventor： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

IPC: A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract translation: 维持，评估和提供肺外治疗的方法和系统。 所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。 长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。 评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。

公开(公告)号：US20090197324A1

公开(公告)日：2009-08-06

申请号：US12099725

申请日：2008-04-08

Applicant: Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

Inventor： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

IPC: A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US09814230B2

公开(公告)日：2017-11-14

申请号：US12099728

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US20090197241A1

公开(公告)日：2009-08-06

申请号：US12099717

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: A01N1/02 ,  A61M16/00 ,  A61B19/00

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US07119671B2

公开(公告)日：2006-10-10

申请号：US10761129

申请日：2004-01-20

Applicant: Ronald Frank ,  Matthew De Remer ,  Adam Young

Inventor： Ronald Frank ,  Matthew De Remer ,  Adam Young

IPC: B60Q1/00

CPC classification number: B60R22/48 ,  B60R21/01546 ,  B60R2021/01265 ,  B60R2022/4816 ,  H05K3/284

Abstract: A seat buckle sensor system is provided that provides an output representative of a lock condition of a seat belt buckle. The system includes a magnet on an end of a seat buckle lock pin and a Hall device. The lock pin, and magnet on the end thereof, move between a locked position and an unlocked position relative to the Hall device. The magnet imparts a first magnetic flux on the Hall device in the locked position causing the Hall device to produce a first output. The magnet imparts a second magnetic flux on the Hall device in the unlocked position causing the Hall device to produce a second output.

Abstract translation: 提供了一种座椅扣式传感器系统，其提供代表安全带扣的锁定状态的输出。 该系统包括在座扣扣销和霍尔装置的一端的磁体。 锁定销和其端部上的磁体相对于霍尔装置在锁定位置和解锁位置之间移动。 磁体在锁定位置的霍尔器件上施加第一磁通，使霍尔器件产生第一输出。 磁体在解锁位置的霍尔器件上施加第二磁通量，从而使霍尔元件产生第二输出。