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    Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
    9.
    发明申请
    Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status 有权
    用于离体器官护理和使用乳酸盐作为供体器官状态的指征的系统和方法

    公开(公告)号：US20070275364A1

    公开(公告)日：2007-11-29

    申请号：US11790405

    申请日：2007-04-25

    申请人： Waleed Hassanein ,  Tamer Khayal ,  Ahmed Elbetanony ,  Paul Lezberg ,  Giovanni Cecere ,  Dennis Sousa ,  Elizabeth Hansen

    发明人： Waleed Hassanein ,  Tamer Khayal ,  Ahmed Elbetanony ,  Paul Lezberg ,  Giovanni Cecere ,  Dennis Sousa ,  Elizabeth Hansen

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0247 ,  A01N1/02

    摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

    摘要翻译： 在各种实施例中，本发明提供了与离体器官护理相关的系统，装置和方法。 在某些实施方案中，本发明涉及在近生理条件下离体维持器官。 本申请描述了在器官护理系统心脏灌注装置的动脉和静脉血管中使用乳酸盐测量的方法来评估：1）孤立心脏的总体灌注状态和2）孤立心脏的代谢状态 和3）分离的供体心脏的整体血管通畅。 本发明的这个方面使用心肌细胞在氧被氧饥饿时产生/产生乳酸的独特能力的特性，并且当它们被氧气充分灌注时代谢/利用乳酸进行能量产生。