专利检索 ap:("Walter D. Celmer" OR "Walter P. Cullen" OR "Charles E. Moppet" OR "John B. Routien" OR "Riichiro Shibakawa" OR "Junsuke Tone") AND inv:"Charles E. Moppet" 第 1 页

1.

发明授权
Mixture of antibiotics produced by a species of actinoplanes 失效
标题翻译：由ACTINOPLANIES种类生产的抗生素混合物

公开(公告)号：US4038383A

公开(公告)日：1977-07-26

申请号：US604260

申请日：1975-08-13

申请人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppet , John B. Routien , Riichiro Shibakawa , Junsuke Tone

发明人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppet , John B. Routien , Riichiro Shibakawa , Junsuke Tone

IPC分类号： A61K35/00 , C07G11/00

CPC分类号： A61K36/06 , C07G11/00 , Y10S435/827

摘要： A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.