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公开(公告)号:US20120020981A1
公开(公告)日:2012-01-26
申请号:US13227157
申请日:2011-09-07
IPC分类号: A61K39/395 , A61P29/00 , A61P37/06 , A61P25/00 , A61P11/06 , A61P35/00 , C07K16/28 , A61P17/06
CPC分类号: C07K16/2866 , C07K16/248 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
摘要翻译: 本发明提供了识别IL-6 / IL-6R复合物的完整的人单克隆抗体。 本发明还提供使用这样的单克隆抗体作为治疗,诊断和预防的方法。
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公开(公告)号:US08337849B2
公开(公告)日:2012-12-25
申请号:US13227157
申请日:2011-09-07
IPC分类号: A61K39/395 , C07K16/28 , C07K16/24
CPC分类号: C07K16/2866 , C07K16/248 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
摘要翻译: 本发明提供了识别IL-6 / IL-6R复合物的完整的人单克隆抗体。 本发明还提供使用这样的单克隆抗体作为治疗,诊断和预防的方法。
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公开(公告)号:US08034344B2
公开(公告)日:2011-10-11
申请号:US12465295
申请日:2009-05-13
IPC分类号: A61K39/395 , C07K16/24 , C07K16/28
CPC分类号: C07K16/2866 , C07K16/248 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
摘要翻译: 本发明提供了识别IL-6 / IL-6R复合物的完整的人单克隆抗体。 本发明还提供使用这样的单克隆抗体作为治疗,诊断和预防的方法。
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公开(公告)号:US20110002936A1
公开(公告)日:2011-01-06
申请号:US12465295
申请日:2009-05-13
CPC分类号: C07K16/2866 , C07K16/248 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
摘要翻译: 本发明提供了识别IL-6 / IL-6R复合物的完整的人单克隆抗体。 本发明还提供使用这样的单克隆抗体作为治疗,诊断和预防的方法。
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公开(公告)号:US20060263363A1
公开(公告)日:2006-11-23
申请号:US11342020
申请日:2006-01-27
申请人: Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
发明人: Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
IPC分类号: A61K39/395 , C07K16/24
CPC分类号: C07K16/249 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFN-γ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder.
摘要翻译: 本发明涉及与人类干扰素γ(hIFNgamma)结合的完全人抗体及其片段,从而调节IFNγ与其受体之间的相互作用,IFNγ-R和/或调节IFN-γ的生物学活性。 本发明还涉及这种抗-γ-抗原γ抗体在预防或治疗免疫相关病症中以及改善与免疫相关病症相关症状的用途。
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公开(公告)号:US20100158922A1
公开(公告)日:2010-06-24
申请号:US12702013
申请日:2010-02-08
申请人: Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
发明人: Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
IPC分类号: A61K39/395 , C07K16/24 , A61P37/06 , A61P29/00 , A61P17/06 , A61P17/00 , A61P9/00 , C12N5/00
CPC分类号: C07K16/249 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFNγ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder.
摘要翻译: 本发明涉及与人类干扰素γ(hIFNγ)结合的完全人抗体及其片段,从而调节IFNγ与其受体IFNγ-R之间的相互作用和/或调节IFNγ的生物学活性。 本发明还涉及这样的抗-γγ抗体在预防或治疗免疫相关病症中以及改善与免疫相关病症相关症状的用途。
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公开(公告)号:US07700098B2
公开(公告)日:2010-04-20
申请号:US11342020
申请日:2006-01-27
申请人: Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
发明人: Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
IPC分类号: A61K39/395
CPC分类号: C07K16/249 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFNγ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder.
摘要翻译: 本发明涉及与人类干扰素γ(hIFNγ)结合的完全人抗体及其片段,从而调节IFNγ与其受体IFNγ-R之间的相互作用和/或调节IFNγ的生物学活性。 本发明还涉及这样的抗-γγ抗体在预防或治疗免疫相关病症中以及改善与免疫相关病症相关症状的用途。
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公开(公告)号:US06171590B2
公开(公告)日:2001-01-09
申请号:US09164186
申请日:1998-09-30
IPC分类号: A61K3816
CPC分类号: C07K14/7158 , A61K39/00
摘要: The present invention provides immunogenic oligopeptides derived from the chemokine receptor protein for use in compositions and methods for the treatment, and prevention of inflammatory responses.
摘要翻译: 本发明提供衍生自趋化因子受体蛋白的免疫原性寡肽,用于组合物和用于治疗和预防炎性反应的方法。
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