公开(公告)号：US20050124971A1

公开(公告)日：2005-06-09

申请号：US10895261

申请日：2004-07-21

申请人： Walter Koch ,  Sitaram Emani ,  Donald Glower ,  Ashish Shah

发明人： Walter Koch ,  Sitaram Emani ,  Donald Glower ,  Ashish Shah

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M31/00

CPC分类号： A61M31/002 ,  A61M25/10 ,  A61M25/10184 ,  A61M2025/0002

摘要： Methods and systems infuse therapeutic materials into a vascular vessel by means of a catheter based infusion system. In especially preferred forms, the infusate (which comprises a therapeutic material) is infused through a distal end of the catheter and into the vascular vessel by delivering the infusate to the catheter at a substantially constant flow rate while simultaneously imparting a pressure amplitude and frequency to the infusate in dependence upon a sensed pressure condition within the vessel. Preferably, and the pressure amplitude imparted to the constant flow rate of infusate is about twice the vessel systolic pressure. The present invention is therefore especially well suited for the catheter-based infusion of relatively large particles, such as cellular, genetic, viral, polymeric or proteinaceous materials, intravascularly in dependence upon the pressure and flow characteristics of the infusate.

摘要翻译： 方法和系统通过基于导管的输注系统将治疗材料注入血管血管。 在特别优选的形式中，输注物（其包括治疗材料）通过导管的远端注入血管，通过以基本上恒定的流速输送到导管，同时将压力幅度和频率提供给 根据感测到的血管内的压力状况输注。 优选地，赋予输注液恒定流速的压力幅度约为容器收缩压的两倍。 因此，本发明特别适用于依赖于输注液的压力和流动特性血管内的相对大的颗粒例如细胞，遗传，病毒，聚合或蛋白质材料的基于导管的输注。